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Évaluation de la Formulation d'Un Comprimé Bicouche de Saxagliptine Et de Repaglinide

Évaluation de la Formulation d'Un Comprimé Bicouche de Saxagliptine Et de Repaglinide

          
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About the Book

Dans le présent travail de recherche, on a tenté d'optimiser et de formuler des comprimés bicouches de saxagliptine et de répaglinide pour obtenir une libération immédiate de la saxagliptine et une libération prolongée du répaglinide.La saxagliptine est un inhibiteur de la DPP-4 et appartient à la classe 1 du BCS (haute solubilité et haute perméabilité). Elle a une longue demi-vie, c'est pourquoi on a essayé d'obtenir une action rapide en fabriquant des comprimés à libération immédiate en utilisant du glycolate d'amidon sodique superdésintégrant. Il est absorbé par voie orale et sa demi-vie est courte, c'est pourquoi on a essayé de fabriquer un comprimé à libération prolongée de répaglinide. On a conclu que la formule optimisée RG4 (75 mg) contenait 98,6 % de médicament en 12 heures. En prenant les deux formules optimisées en combinaison à dose fixe dans différentes couches, on a préparé un comprimé bicouche avec 50 mg de saxagliptine et 500 mg de répaglinide.


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Product Details
  • ISBN-13: 9786206494904
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Notre Savoir
  • Height: 229 mm
  • No of Pages: 64
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 620649490X
  • Publisher Date: 27 Sep 2023
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 104 gr


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Évaluation de la Formulation d'Un Comprimé Bicouche de Saxagliptine Et de Repaglinide
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