Depression, a state of psychological disorder, is a major cause of the evils threatening the world and respecting none regardless of the amount of wealth, connections, public status and influence. Facts show that depression is a self-inflict and can be managed effectively by self provided right steps are taken at the right time towards the right direction. The wise says 'the best way to manage crisis is to avoid crisis'. Individuals, institutions, associations and nations facing the scourge of depression from different angles and degrees need to do certain works in identifying the root causes and deracinate them to end or minimise the side effects of depression on people and their businesses, social, economic and political. The adverse effects of climate change are traced to the misuse of the environment by the people who are depressed. The terrorist organizations are populated by the people who are depressed. Unfortunately, peace eludes the world simply because the depressed people are leaders at homes, offices, institutions and nations. This simple assertion shows that all are depressed and we live with depression. By studies, the word 'depression' is another word for sadness. Efforts of the specialized professionals to have lasting therapy for the victims or the patients of depression proved abortive. The drugs and injections being administered are not doing the needful. Failure of the cure to the symptoms result in greater signs of terminal diseases that are emptying the pockets and liquidating the financial resources of the people, institutions, associations, professional bodies and nations. Today, loneliness and unhappiness is rising by the day at homes, offices and places of interest resulting in the addiction to alcohols, hard drugs, gambling and other illicit activities. The transfer of bad sides of depression transforms into street violence, low productivity, low income, poor standard of living, tribal wars and cultism which threaten the population and the downgrade of values. The work is a research guide to all students and tutors of psychology and sociology.Our studies confirm that all that give pleasure are the sources of depression if care is not taken. The state and nation that open new ministries of happiness and loneliness respectively have enough reasons to have them set up for the love of their people. When a sick could not find cure for his or her depression, he or she engages in a more endangering self-medication exercise leading to suicide and recurring deadly illnesses. The hopes are apparently lost in the use of drugs and injections to cure depression and therefore the needs for further materials that could end the scourge of depression.Author Amusa Abdulateef in his style has carried out studies to produce solutions to the apparently insurmountable challenges in the world with the use first hand experiences and the references to open the eyes of the readers to how to effectively and efficiently handle the victims of depression at homes, hospitals and other places. This book shall boost the low spirits of the readers especially those suffering from depression and turn their hearts a peaceful abode for positive things that can impact the other lives and nations. By the strict adherence to the do's and don'ts, people shall be totally cure from all the symptoms of depression and its group of illness with self-discipline and attitudinal changes to materialistic life by individuals occupying positions at homes, communities, in the institutions, professional bodies, social clubs and associations and governments without the use of drugs and injections.