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Wirkung von Corcumin auf das Kleinhirn einer hypothyreoten Ratte

Wirkung von Corcumin auf das Kleinhirn einer hypothyreoten Ratte

          
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About the Book

Schilddrüsenhormone spielen eine wichtige Rolle im Gehirn, insbesondere während der Entwicklung. Eine Veränderung des Hormonspiegels wirkt sich auf das Wachstum und die Alterung von Tieren aus. Eine der wichtigsten Funktionen der Schilddrüsenhormone ist jedoch die strenge Regulierung des zellulären Sauerstoffverbrauchs und der daraus resultierenden Erzeugung von ROS in verschiedenen Geweben, einschließlich des Gehirns. In der vorliegenden Studie wurde festgestellt, dass eine Hypothyreose Veränderungen bei antioxidativen Enzymen, oxidativen Stressparametern und histologischen Veränderungen im sich entwickelnden Kleinhirn hervorruft. Dies könnte auf seine Fähigkeit, freie Radikale zu fangen, zurückzuführen sein. Es reduziert den normalen Gehalt an freien Radikalen in den Geweben und stellt einen oxidativen Mangelzustand her. Eine andere Erklärung dafür könnte sein, dass es sich um eine physiologische Anpassung handelt, bei der die Aktivitäten der Enzyme bei niedrigen Substratspiegeln reduziert werden. Eine Hypothyreose geht mit einem hypometabolischen Zustand und einem geringeren Sauerstoffverbrauch einher, wodurch weniger ROS freigesetzt werden. Bei niedrigen Substratspiegeln kann die Aktivität der antioxidativen Enzyme geringer sein, was sich in dieser Studie widerspiegelt.


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Product Details
  • ISBN-13: 9786207606238
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Verlag Unser Wissen
  • Height: 229 mm
  • No of Pages: 52
  • Spine Width: 3 mm
  • Width: 152 mm
  • ISBN-10: 620760623X
  • Publisher Date: 30 May 2024
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 91 gr


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Wirkung von Corcumin auf das Kleinhirn einer hypothyreoten Ratte
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