The Washington Manual® of Oncology, Second Edition presents the latest, most authoritative cancer management recommendations in the famous fast-access Washington Manual® outline format. This edition has been reorganized into three major sections principles of oncology, site-specific diseases, and supportive therapy. New chapters cover being an oncologist; principles of cytotoxic therapy; principles of molecularly targeted therapy; principles of clinical research; basics of molecular oncogenesis; pharmacogenomics; molecular diagnostics; cancer and thrombosis; management of complications of chemotherapy; and transfusion medicine. New appendices cover body surface area, dose adjustments of chemotherapy agents in renal and hepatic failure, and online resources for oncologists. The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by LWW under license from Washington University. Table of Contents On Being an Oncologist, Ramaswamy Govindan Principles and Practice of Surgery in Cancer Therapy, Elbert Y. Kuo, Steven E. Finkelstein, and Rebecca L. Aft Principles and Practice of Radiation Therapy, Jeffrey D. Bradley, Joseph Roti Roti, and Sasa Mutic Principles of Systemic Cancer Therapy: Cytotoxic Therapy, Kristan M. Augustin Principles of Systemic Cancer Therapy: Molecularly Targeted Therapy, Lindsay M. Hladnik, Angela R. Wills, and Kristan M. Augustin Principles of Stem Cell and Bone Marrow Transplantation, John DiPersio Biostatistics 101 as Applied to Oncology, Kathryn M. Trinkhaus, Feng Gao, and Philip Miller Principles of Clinical Research, Feng Gao and Ramaswamy Govindan Basics of Molecular Oncogenesis, John D. Pfeifer Pharmacogenomics, Richard A. Walgren and Howard L. McLeod Molecular Diagnostics, Barbara Zehnbauer and John D. Pfeifer Neuro-oncology, Dennis Rivet, Michael R. Chicoine, Gerald P. Linette, and Joseph R. Simpson Head and Neck Cancer, David Kuperman, Matthew Arquette, and Douglas Adkins Lung Cancer, Ramaswamy Govindan and Janakiraman Subramanian Breast Cancer, Rama Suresh and Mathew J. Ellis Thymoma and Mesothelioma, Daniel Morgensztern Gastrointestinal Cancer: Esophageal and Stomach, David Kuperman and Maria Baggstrom Gastrointestinal Cancer: Colorectal and Anal, Benjamin R. Tan Gastrointestinal Cancer: Hepatobiliary and Pancreatic, Steven M. Sorscher Genitourinary Cancer: Kidney, Michael Naughton and James Mosley Genitourinary Cancer: Bladder, Joel Picus Genitourinary Cancer: Prostate, Ramakrishna Venkatesh Genitourinary Cancer: Penile, Steven Brandes and Joel Picus Germ Cell Tumors: Testicular and Non-testicular, Donald Lombardi Gynecologic Cancer: Ovarian, Ashley S. Case and Matthew A. Powell Gynecologic Cancer: Uterine, Cervical, Fallopian, and Vulvar , Rebecca A. Brooks, Matthew A. Powell, and David G. Mutch Hematologic Malignancies: Lymphoma, Nancy Bartlett Hematologic Malignancies: Acute Leukemias, Amanda Cashen Hematologic Malignancies: Chronic Leukemias, Todd A. Fehniger, John S. Welch, and Timothy J. Pluard Hematologic Malignancies: Plasma Cell Dyscrasias, Tanya Wildes and Ravi Vij HIV and Cancer, Lee Ratner and Benjamin Tan Sarcoma, David Kuperman and Douglas Adkins Malignant Melanoma and Non-Melanoma Skin Cancer, Paul A. Klekotka, Lynn A. Cornelius and Gerald P. Linette Cancer of Unknown Primary Site, Daniel Morgensztern Cancer and Thrombosis, Charles Eby Oncologic Emergencies, Vamsidhar Velcheti and Ramaswamy Govindan Management of Complications of Chemotherapy, Eve Gilstrap and Beth Zubal Growth Factor Support in Oncology, Rama Suresh Transfusion Medicine, Joshua Field, Douglas Lublin, and George Despostis Nutritional Support, Carolina Javier Smoking Cessation and Counselng, Megan E. Wren Pain Management, Robert A. Swarm, Rahul Rastogi, and Daniel G. Morris Hospice and Palliative Care, Colleen R. Gilmore