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Untersuchungen zur Resorption und Differenzierungseffekten von Propionat in der intestinalen Zellinie Caco-2

Untersuchungen zur Resorption und Differenzierungseffekten von Propionat in der intestinalen Zellinie Caco-2

          
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About the Book

Inhaltsangabe: Zusammenfassung: In den letzten Jahren wurde mit großem Interesse die physiologische Rolle der kurzkettigen Fettsäuren für die normale Funktionsfähigkeit des Kolons und ihre antineoplastischen Eigenschaften studiert. Das Ziel der vorliegenden Untersuchung war, die Rolle des Propionats mit seiner protektiven Wirkung im Hinblick auf Dickdarmkrebs nachzuweisen. Bislang wurde in erster Linie die Bedeutung des Butyrats herausgestellt. Anhand der Kolonkarzinomzellinie Caco-2 konnte der suppressive Effekt des Propionats auf das Zellwachstum und seine Eigenschaft als Differenzierungsagens nachgewiesen werden. Zum ersten Mal ist auch, im Hinblick auf die Entstehung von Karzinomen, der protektive Effekt des Propionats aufgrund der stimulierenden Wirkung gegenüber der GST-* beobachtet worden. Die GST-* stellt ein wichtiges Detoxifikationssystem dar, das in höheren Konzentrationen effektiver die Zelle vor Karzinogenen schützen kann. Dagegen konnte eine gesteigerte Proliferationsneigung der Caco-2 Zellen unter dem Einfluß der Desoxicholsäure nicht eindeutig gezeigt werden. Die Ergebnisse der Transportuntersuchungen deuten auf eine nichtionische Diffusion der SCFAs hin. Bei diesem Resorptionsprozeß konnte der genaue Ablauf des Mechanismus nicht geklärt werden, jedoch ist die Beteiligung des Na+/K+-Antiporters auszuschließen. Im Zusammenhang mit der inhibitorischen Wirkung von Mercapto- und Brompropionat auf den Propionattransport, konnte kein suppressiver Effekt beobachtet werden. Aufgrund dieser Ergebnisse haben sich für weitere Studien neue Ansatzpunkte zum Transportmechanismus und Differenzierungseffekt der SCFAs, sowie zum suppressiven Einfluß der Mercapto- und Bromoanaloga ergeben. Inhaltsverzeichnis: Inhaltsverzeichnis: 1.Einleitung1 1.1Einführung und Problemstellung1 1.2Grundlagen und Bedeutung der kurzkettigen Fettsäuren5 1.2.1Produzenten und Produktionsort der kurzkettigen Fettsäuren5 1.2.2Substrate für die Produktion der kurzkettigen Fettsäu


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Product Details
  • ISBN-13: 9783838605357
  • Publisher: Diplom.de
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Spine Width: 7 mm
  • Width: 148 mm
  • ISBN-10: 3838605357
  • Publisher Date: 27 Nov 1997
  • Height: 210 mm
  • No of Pages: 108
  • Series Title: German
  • Weight: 154 gr


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Untersuchungen zur Resorption und Differenzierungseffekten von Propionat in der intestinalen Zellinie Caco-2
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