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Uma avaliação comparativa da capacidade de melhoria da memória de espécies de Ocimum

Uma avaliação comparativa da capacidade de melhoria da memória de espécies de Ocimum

          
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About the Book

As plantas são muito apreciadas como potenciadoras das funções cognitivas. As plantas ricas em polifenóis são muito promissoras para o tratamento de doenças neurodegenerativas. Neste estudo, algumas espécies comuns de Ocimum ricas em polifenóis, ou seja, O. basilicum, O. gratissimum e O. sanctum, foram examinadas quanto ao seu potencial anti-amnésico. Os extractos das três espécies seleccionadas foram examinados através de testes in-vitro para determinar a sua capacidade antioxidante e de acetilcolinesterase. Com base nos resultados in-vitro, o extrato mais ativo foi investigado para determinar a sua atividade de melhoria da memória utilizando um modelo de demência em ratos. O extrato de Ocimum basilicum tinha o teor mais elevado de fenóis totais e demonstrou o potencial antioxidante e inibidor da acetilcolinesterase mais significativo in-vitro. Nos estudos in vivo, o tratamento com o extrato de O. basilicum durante 7 dias melhorou a perturbação da memória induzida pela escopolamina nos animais, juntamente com uma redução significativa da atividade da AChE e dos parâmetros de stress oxidativo (redução dos níveis de TBARS e aumento da atividade da GSH) na região do hipocampo e do córtex cerebral. Este produto pode ser desenvolvido como um potenciador da cognição após testes pormenorizados.


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Product Details
  • ISBN-13: 9786207595402
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 52
  • Spine Width: 3 mm
  • Width: 152 mm
  • ISBN-10: 6207595408
  • Publisher Date: 29 May 2024
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 91 gr


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