Excerpt from The Treasury of Human Inheritance: With 11 Plates of Pedigrees and 1 Plate in Colours, Plates 14-24, Plate F Pedigrees 73-192

Generation. IV. 1 - 6, children of III. 2 and III. 3. The three sons had each one foot enlarged, the limbs of the three daughters being normal. The order of birth of these children is not stated. IV. 7 and IV. 8, the eight children of III. 4 and III. 5. One of the eight, a boy, has one enlarged foot, the other seven being normal, three of the seven are dead. IV. 9 - IV. 14, the five children of III. 7 and III. 8, the youngest - sex rl - has an enlarged oedematous foot, the others being normal. IV. 15 and 16, the four children of III. 9 and III. 10. The youngest, sex not stated, has an oedematous leg. IV. 17, IV. 18, IV. 19, three children of III. 11 and III. 12. Only the boy, IV. 19, was affected and suffered from enlarged foot. When he reached maturity his testicles began to swell and progressed to such an extent that one of them had to be removed. Strange to say as the testicle increased in Size the oedematous foot decreased and after the operation became and remained normal. IV. 20 and IV. 21, children of III. 15. By her first husband the three children (sex not stated) were normal, whereas by her second husband she had a son, IV. 21, with great oedema of both feet and both legs up to the level of the knees. The left side was more oedematous however than the right. IV. 21, an American clergyman, was the patient who consulted Milroy and whose condition led to Milroy's enquiry into the family history. V. 1, 2, and 3, the 11 grandchildren of III. 2 and III. 3. Of them is stated that two, viz. A son and a daughter, were affected with the family disease. In both cases the foot alone on one side was affected. The respective parents of these children are not given. V. 4, nine grandchildren of III. 4 and III. 5, sex and order of birth not stated, none of them were oedematous. V. 5, V. 6, V. 7, nine grandchildren of III. 7 and III. 8. Their order of birth and in seven cases, V. 5, the sex not stated. V. 6, the son of the eldest daughter of III. 7 has both legs enlarged, while V. 7 the son of the eldest son of III. 8 has one foot enlarged. The exact parentage of V. 5, V. 6 and V. 7 is not clear from Milroy's account. V. 9, V. 10, V. 11, V. 13, grandchildren of III. 9 and III. 10. One, a son, V. 10 has an enlarged foot, the other children being unaffected. V. 8 wife of V. 9, and V. 12 the Wife of V. 11, presumably normal. V. 14 and 15, two normal grandchildren (sex of III. 11 and III. 12. V. 16, 13 normal grandchildren of III. 15. The exact parentage of these 13 children not stated. VI. 1, three normal children (sex 1) of V. 8 and V. 9. VI. 2, has one enlarged foot. VI. 3, sex not stated but alleged not to be oedematous. VI. 4, has both feet enlarged. VI. 5, two great grandchildren of III. 15, age and sex not given, but stated not to suffer from oedema. In Milroy's family of 97 individuals there were 22 cases of oedema or about 23 of the whole number. With three exceptions the disease was congenital and progressive, the exceptions being: (1) III. 9, whose normal leg began to enlarge after a carriage accident. (2) III. 15, who was normal till the age of 12. (3) IV. 19, whose oedema disappeared after the removal of a testicle. With reference to the sex incidence there were twelve affected males, eight females and two the sex of which was not determined. (see Bibl. No.

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