Home > Technology & Engineering > Technology: general issues > Transcriptome analysis of TRPV1-positive rat dorsal root ganglion neurons: Nociception and the underlying molecular mechanisms
Transcriptome analysis of TRPV1-positive rat dorsal root ganglion neurons: Nociception and the underlying molecular mechanisms

Transcriptome analysis of TRPV1-positive rat dorsal root ganglion neurons: Nociception and the underlying molecular mechanisms

          
5
4
3
2
1

Out of Stock


Premium quality
Premium quality
Bookswagon upholds the quality by delivering untarnished books. Quality, services and satisfaction are everything for us!
Easy Return
Easy return
Not satisfied with this product! Keep it in original condition and packaging to avail easy return policy.
Certified product
Certified product
First impression is the last impression! Address the book’s certification page, ISBN, publisher’s name, copyright page and print quality.
Secure Checkout
Secure checkout
Security at its finest! Login, browse, purchase and pay, every step is safe and secured.
Money back guarantee
Money-back guarantee:
It’s all about customers! For any kind of bad experience with the product, get your actual amount back after returning the product.
On time delivery
On-time delivery
At your doorstep on time! Get this book delivered without any delay.
Notify me when this book is in stock
Add to Wishlist

About the Book

Diploma Thesis from the year 2011 in the subject Medicine - Biomedical Engineering, grade: 1,0, Technical University of Berlin (Biotechnologie), language: English, abstract: Pain is an unpleasant sensory and emotional experience and an essential component of the body's defense system. Noxious stimuli are detected by special afferent sensory neurons called nociceptors (or nociceptive neurons), which connect peripheral tissues with the central nervous system. Noxious signals travel along the nociceptor to the dorsal horn of the spinal cord from where they projected to higher brain regions via 2nd order neurons. After evaluation in brain stem, thalamus, and cortex a complex sensory perception arises: Pain. Extensive research has been performed to gain insight into molecular mechanisms of pain sensation and its modulation. Many of the transduction channels that convert thermal, mechanical or chemical stimuli into electrical activity are transient receptor potential (TRP) ion channels, which are widely expressed in nociceptors and play a prominent role in pain sensation. Still many transduction molecules that trigger pain have not been discovered. To identify transcripts enriched in TRPV1-positive neurons I used the ability to activate these channels with the specific agonists capsaicin and resiniferatoxin (RTX). The resulting calcium influx changes structural properties and thus alters the density of TRPV1-positive neurons. This enables their separation via density gradient centrifugation. In comparison to a control group (including TRPV1-positive neurons) this newly developed method allows me to find predominantly expressed genes in TRPV1-positive neurons. To validate the depletion I utilized western blot, immunocytochemistry and qPCR. The results showed effective depletion of TRPV1-postitive neurons for up to 95%. Subsequent gene expression analysis revealed promising candidates that were highly enriched in TRPV1-positive neurons. The candidate genes were classified a


Best Sellers



Product Details
  • ISBN-13: 9783668251793
  • Publisher: Grin Publishing
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 7 mm
  • Weight: 150 gr
  • ISBN-10: 3668251797
  • Publisher Date: 12 Aug 2016
  • Height: 210 mm
  • No of Pages: 108
  • Series Title: English
  • Sub Title: Nociception and the underlying molecular mechanisms
  • Width: 148 mm


Similar Products

How would you rate your experience shopping for books on Bookswagon?

Add Photo
Add Photo

Customer Reviews

REVIEWS           
Click Here To Be The First to Review this Product
Transcriptome analysis of TRPV1-positive rat dorsal root ganglion neurons: Nociception and the underlying molecular mechanisms
Grin Publishing -
Transcriptome analysis of TRPV1-positive rat dorsal root ganglion neurons: Nociception and the underlying molecular mechanisms
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Transcriptome analysis of TRPV1-positive rat dorsal root ganglion neurons: Nociception and the underlying molecular mechanisms

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book
    Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals



    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!