Excerpt from Transactions of the Pathological Society of London, Vol. 53: Comprising the Report of the Proceedings for the Session 1901-1902

If any conclusions can be drawn at all, we should infer from Table VIII that the average daily output of coagulable proteid in the urine was almost constant in the different periods; that the addition of bread or Liebig to our patient's diet did not cause it to alter much; that in the uraemic period the average total for each twenty-four hours was approximately the same as the average for the whole period; and that the average daily total was more constant than the average percentage relation ship to the total nitrogen in the urine.

It is true that when Liebig was added to the diet there was an increase in the coagulable proteid for the first few days; the last two days with milk diet, before Liebig was given, gave an average of 05417 gramme nitrogen as albumen the average of the first two days of Liebig was gramme nitrogen. The average for the whole Liebig period gramme), on the other hand, was less than the average for the whole period of milk diet gramme). The change, however, from milk to milk and bread or biscuit gave a fall in coagulable proteid nitrogen from gramme to 04479 gramme. We do not find, therefore, as Van N corden (64) did, that change of diet always caused an increase in the albumen.

The detailed figures in Table I show the coagulable proteid nitrogen to have been highest on March lst and 2nd, namely, on the first day of distinct uraemia and on the day before it, but this may be mere coincidence. It is of interest to compare the figures with the clinical account; it will be seen that the oedema was, as far as we could judge, most marked about March 20th 5 the coagulable proteid nitrogen was by no means at its maximum at this time. The total amount of coagulable proteid in the urine gave no close index of the oedema present.

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