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Toxicité Hépatique de l''homocystéine Et Polyphénols

Toxicité Hépatique de l''homocystéine Et Polyphénols

          
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About the Book

L'augmentation du taux plasmatique d'homocystéine est associée à un accroissement du risque de développer une maladie coronaire ou cérébrovasculaire. Les premières études sur des souris déficientes en cystathionine bèta synthase (CBS), un modèle d'hyperhomocystéinémie ont révélé une stéatohépatite . La première partie de ce travail a consisté à étudier les mécanismes moléculaires impliqués dans l'apparition de la stéatohépatite chez les souris déficientes en CBS. Nous avons ainsi montré que l'état inflammatoire chronique est associé à l'activation de la voie NF-B. D'autre part, nous avons montré que la déficience en CBS entraîne une dérégulation de l'homéostasie hépatique du cholestérol qui permet d'expliquer la stéatose. Une deuxième partie du travail a consisté à tester l'utilisation de la catéchine, un polyphénol, comme traitement contre l'hyperhomocystéinémie. Nous avons soumis des souris hyperhomocystéinémiques à un régime riche en catéchine. Nous avons ainsi pu montrer que la catéchine entraîne une diminution de la concentration plasmatique en homocystéine et une augmentation de l'activité hépatique de la paraoxonase 1, une enzyme aux propriétés anti-athérogéniques.


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Product Details
  • ISBN-13: 9786131566523
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Height: 229 mm
  • No of Pages: 208
  • Series Title: Omn.Univ.Europ.
  • Weight: 313 gr
  • ISBN-10: 6131566526
  • Publisher Date: 28 Feb 2018
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 12 mm
  • Width: 152 mm


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