Thermodynamic degradation science is a new and exciting discipline. It contributes to both physics of failure and as a new area in thermodynamics. There are many different ways to approach the science of degradation. Since thermodynamics uses an energy perspective, it is a great way to analyze such problems. There is something in this book for everyone who is concerned with degradation issues. Even if you are just interested in reliability or accelerated testing, there is a lot of new and highly informative material. We also go beyond traditional physics of failure methods and develop conjugate work models and methods. It is important to have new tools. a conjugate work approach to solving physics of failure problems. We cover a number of original key topics in this book, including: -thermodynamic principles of degradation-predicting life using the free energy-conjugate work, entropy damage, and free energy degradation analysis;-physics of failure using conjugate work approach;-complex systems degradation analysis using noise analysis;-mesoscopic noise entropy measurement for disorder in operating systems;-human heart degradation noise measurements;-cumulative entropy damage, cyclic work, and fatigue analysis;-Miner's rule derivation for fatigue and Miner's rule for batteries;-engines and efficiency degradation;-aging laws, cumulative accelerated stress test (CAST) plans, and acceleration factors for: creep; wear; fatigue; thermal cycle; vibration (sine and random); temperature; humidity and temperature;-transistor aging laws (bipolar and FET models);-new accelerated test environmental profiling CAST planning method;-vibration cumulative damage (sine and random);-chemical corrosion and activations aging laws;-diffusion aging laws;-reliability statistics;-how aging laws affect reliability distributions;-human engine degradation;-human heart versus metal cyclic fatigue;-human growth and repair model;-negative entropy and spontaneous negative entropy; and-environmental degradation, climate change, and pollution.When we think of thermodynamic degradation, whether it be for complex systems, devices, or even human aging, we begin to realize that it is all about "order" being converted to "disorder" due to the natural spontaneous tendencies described by the Second law of thermodynamics to come to equilibrium with the neighboring environment. Although most people who study thermodynamics are familiar with its second law, not many think of it as a good explanation of why a product degrades over time. However, we can manipulate and rephrase it as follows. The second law in terms of system thermodynamic degradation: the spontaneous irreversible degradation processes that take place in a system interacting with its environment will do so in order to go towards thermodynamic equilibrium with its environment.We see that the science presents us with a gift, for its second law actually explains the aging processes. This is a second edition, prior to the first edition, a preview chapter was as an invited contributor to a book edited with Professor Swingler at Heriot-Watt University, Edinburgh, entitled The Physics of Degradation in Engineered Materials and Device. We see that this science is starting to catch on. This book presents the fundamentals and goes beyond including new ways to make measurements, and provides many examples so the reader will learn the value of how this science can be used. I believe this science will significantly expand soon and it is my hope that this book will provide the spark to inspire others. Thermodynamic degradation science offers new tools, new ways to solve physics of failure problems, and new ways to do prognostics and prevent failure.