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Terapia genowa w leczeniu raka piersi

Terapia genowa w leczeniu raka piersi

          
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About the Book

Rak piersi jest najczęstszym rodzajem nowotworu u kobiet. Większośc przypadków dziedzicznych związana jest z mutacjami genów związanych z rakiem piersi (BRCA). Profilaktyczna mastektomia i chemoprewencja są jedynymi dostępnymi dotychczas metodami zapobiegania rozwojowi nowotworów u pacjentek o określonym pochodzeniu genetycznym. Jednak efekty uboczne i inwazyjnośc tych zabiegów sprawiają, że konieczne jest opracowanie alternatywnych strategii. Niniejsza książka opisuje nowatorskie podejście do zapobiegania rakowi piersi oparte na odtworzeniu funkcjonalnego genu BRCA1 do komórek docelowych za pomocą zmodyfikowanego wirusa. W rzeczywistości wirusy opracowaly skuteczny mechanizm dostarczania swojego materialu genetycznego do komórek docelowych; wektory pochodzące od wirusa wykorzystują tę zdolnośc do wehykulacji komórek transgenowych. W tym celu wyprodukowano wektor lentiwirusowy wyrażający gen BRCA1. Przywrócenie funkcji genu zostalo zwalidowane w komórkach nowotworowych i pierwotnych pochodzących od pacjenta kodującego nieaktywną formę BRCA1, która po dostarczeniu genu przywracala zdolnośc do naprawy uszkodzeń DNA po ekspozycji na promieniowanie jonizujące. Wyniki te torują drogę do opracowania nowych metod zapobiegania rakowi ludzkiej piersi.


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Product Details
  • ISBN-13: 9786202959438
  • Publisher: Wydawnictwo Nasza Wiedza
  • Binding: Paperback
  • Language: Polish
  • Returnable: N
  • Weight: 136 gr
  • ISBN-10: 6202959436
  • Publisher Date: 22 Oct 2021
  • Height: 229 mm
  • No of Pages: 84
  • Spine Width: 5 mm
  • Width: 152 mm


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