In the Spring of 1587, 120 Londoners loaded onto three ships to set sail to the New World. Sir Walter Raleigh had offered them 500 acres each to start a colony in what he had named Virginia. John White was the leader of this group. His daughter Eleanor and son-in-law Ananias were among them. Eleanor was pregnant with what she calculated would be the first English baby born across the ocean.

After a harrowing voyage, their Portuguese ship captain dumped them all off several miles south of their intended landing site on the Chesapeake Bay. Trying to make do on Roanoke Island, one of the colonists was murdered by one of the local Native American tribes, making their situation fraught with fear. John White set off back to England to try to get help for the colonists. They needed food, soldiers, cows, chickens, and more colonists.

One man aboard the ship was glad to be back in the New World because it was his home. His name was Manteo and he was a well-respected member of the Croatoan tribe who lived just inland from Roanoke Island. He had become good friends with Eleanor Dare on the voyage, teaching her to speak his native language. Manteo was an excellent hunter and fisherman and helped feed the British colonists with venison and seafood.

The situation deteriorated and it became known that although the Croatoans were friendly to the British, other tribes wanted them all dead. Ananias was killed while he and Manteo were away from the encampment. Manteo immediately suggested to Eleanor that she and her baby, Virginia, accompany him to his village. The rest of the British would have to fend for themselves heading south to try to outrun the hostile tribesmen.

Eleanor was accepted into Manteo's tribe partly because she had learned their language and partly because she was a new mother. The medicine woman of the tribe, Alsoome, took her in and introduced her to the women of the tribe, finding her a wet nurse for Virginia as Eleanor did not have enough milk for her daughter.

Eleanor convinced Manteo to take her back to the British encampment to leave a message for her father who she was sure would be back with help in a few months. She carved the word Croatoan on a tree to let him know where she was. While there they found one of the young boys from the expedition, nearly dead from thirst and hunger. As they nursed him back to health, they learned from him the fate of all the other colonists. Dead. Every one of them.