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Sistemi di somministrazione orale di farmaci mirati al colon per il tinidazolo

Sistemi di somministrazione orale di farmaci mirati al colon per il tinidazolo

          
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About the Book

Il tinidazolo è il farmaco di elezione nel trattamento dell'amebiasi, un'infezione dell'intestino crasso causata da Entamoeba histolytica, un parassita protozoo unicellulare che ogni anno causa 34-50 milioni di infezioni sintomatiche ed è responsabile fino a 1.000.000 di decessi. L'esigenza del momento è quella di progettare sistemi di somministrazione orale mirata al colon per il tinidazolo che possano non solo aumentare la presenza del farmaco a livello locale per un periodo prolungato, ma anche ridurre il rischio di tossicità sistemica come risultato della riduzione della dose in questo approccio specifico. Le formulazioni sono state progettate per ottenere un rilascio minimo durante il primo periodo di ritardo di 6 ore, seguito da un rilascio completo e controllato nelle successive 18 ore. I due approcci adottati per raggiungere questo obiettivo sono il sistema di rilascio microbicamente dipendente e il sistema di rilascio dipendente dal tempo. La strategia per lo sviluppo di sistemi di rilascio di farmaci microbicamente dipendenti consiste nello sfruttare l'attività enzimatica specifica della microflora presente nel colon, mentre la strategia per la progettazione di sistemi a rilascio temporizzato consiste nel resistere all'ambiente acido dello stomaco e nel rilasciare il farmaco dopo un tempo di ritardo predeterminato.


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Product Details
  • ISBN-13: 9786205365397
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 84
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 6205365391
  • Publisher Date: 17 Nov 2022
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 136 gr


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