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Role of the P53/P21 System in the Response of Human Colon Carcinoma Cells to Doxorubicin

Role of the P53/P21 System in the Response of Human Colon Carcinoma Cells to Doxorubicin

          
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About the Book

Colon adenocarcinomas are refractory to a number of widely used anticancer agents. Multifactorial mechanisms have been implicated in this intrinsically resistant phenotype, including deregulation of cell death pathways. In this regard, the p53 protein has a well established role in the control of tumor cell response to DNA damaging agents; however, the relationship between p53-driven genes and drug sensitivity remains controversial. The present study investigates the role of the p53/p21 system in the response of human colon carcinoma cells to treatment with the cytotoxic agent doxorubicin (DOX) and the possibility to modify the therapeutic index of DOX by modulation of p53 and/or p21 protein levels. p21 induction may significantly contribute to the response of colon adenocarcinomas cells to DOX treatment; and small molecules that can exploit p53-independent pathways for p21 induction, such as TPL, may find a place in chemotherapeutic protocols for the clinical management of colorectal cancer, where p53 function is often lost, due to genetic or epigenetic defects or to post-transcriptional inactivating mechanisms. Proceeds from the sale of this book go to support an elderly disabled person.


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Product Details
  • ISBN-13: 9781517127367
  • Publisher: Createspace Independent Publishing Platform
  • Publisher Imprint: Createspace Independent Publishing Platform
  • Height: 275 mm
  • No of Pages: 40
  • Series Title: English
  • Weight: 15436 gr
  • ISBN-10: 151712736X
  • Publisher Date: 14 Dec 2018
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 3 mm
  • Width: 213 mm


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Role of the P53/P21 System in the Response of Human Colon Carcinoma Cells to Doxorubicin
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