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Resistenza agli antibiotici aminoglicosidi attraverso la metilazione dell'RNA ribosomiale

Resistenza agli antibiotici aminoglicosidi attraverso la metilazione dell'RNA ribosomiale

          
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About the Book

Nei batteri produttori di antibiotici due famiglie di metiltrasferasi 16S rRNA (MT) forniscono resistenza contro l'autointossicazione: Kam MT (m1A1408) e Kgm MT (m7G1405). Entrambe queste MT hanno i loro omologhi nei batteri patogeni, le famiglie Arm e Pam MT, rispettivamente. Questi MT agiscono a livello dei nucleotidi nel sito di legame antibiotico e l'aggiunta di gruppi metilici blocca stericamente il legame antibiotico. Gli studi su Sgm di M. zionensis hanno fornito alcune intuizioni iniziali sulla MT di Kgm utilizzando la conservazione delle sequenze e la modellazione dell'omologia. Le strutture recenti hanno mostrato che la resistenza MT, indipendentemente dalla loro origine, ha la stessa piega proteica. Tuttavia, le sequenze proteiche corrispondenti non riflettono la conservazione della struttura che indica che una particolare piega proteica può essere ottenuta con sequenze che condividono solo il 30% di identità. Allo stesso tempo la conservazione della struttura proteica indica che i vincoli strutturali sono importanti per un'efficiente selezione dei nucleotidi target sul 16S rRNA. La questione chiave futura sarà quella di determinare il meccanismo molecolare della selezione del sito target e se le caratteristiche specifiche del riconoscimento possono essere sfruttate per combattere l'aumento della resistenza agli antibiotici aminoglicosidici clinicamente utili.


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Product Details
  • ISBN-13: 9786203213720
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 144
  • Spine Width: 9 mm
  • Width: 152 mm
  • ISBN-10: 6203213721
  • Publisher Date: 13 Jan 2021
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 222 gr


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