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Requirements of T cell-driven Autoimmunity in Alymphoplastic Mice

Requirements of T cell-driven Autoimmunity in Alymphoplastic Mice

          
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About the Book

Secondary lymphoid tissues (SLTs) are an absolute requirement for lymphocyte activation. Alymphoplastic (NIK-aly/aly) mice lack lymph nodes and display impaired immunity. The malformations of NIK-aly/aly mice are due to a mutation in the NFkB-inducing kinase (NIK). NIK is involved in the formation of SLTs during development. To our surprise, we found that the immunodeficiency of NIK-aly/aly mice results from the impact of NIK on T cell priming but not from the lack of SLTs. We describe an alternative pathway for the induction of cell-mediated immunity, in which antigen-presenting cells sample antigen and migrate into the liver where they induce neo-lymphoid aggregates. We further demonstrate that the NIK-lesion in NIK-aly/aly mice does not cause an intrinsic T cell defect but leads to the failure of dendritic cells to licence CD4+ effector lineages. In detail we discovered that a population of thymic DCs requires NIK and is capable to shape the formation of T effector lineages during thymic T cell development.


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Product Details
  • ISBN-13: 9783838132082
  • Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 8 mm
  • Width: 152 mm
  • ISBN-10: 3838132084
  • Publisher Date: 16 Mar 2012
  • Height: 229 mm
  • No of Pages: 128
  • Series Title: English
  • Weight: 199 gr


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Requirements of T cell-driven Autoimmunity in Alymphoplastic Mice
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Requirements of T cell-driven Autoimmunity in Alymphoplastic Mice
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