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Prätherapeutische I-124 PET(/CT)-Speicheldrüsendosimetrie bei der Radiojodtherapie differenzierter Schilddrüsenkarzinome: Untersuchung von wichtigen Einflussfaktoren auf die I-124 Quantifizierung

Prätherapeutische I-124 PET(/CT)-Speicheldrüsendosimetrie bei der Radiojodtherapie differenzierter Schilddrüsenkarzinome: Untersuchung von wichtigen Einflussfaktoren auf die I-124 Quantifizierung

          
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About the Book

Doktorarbeit / Dissertation aus dem Jahr 2010 im Fachbereich Medizin - Therapie, Note: 2, Universität Duisburg-Essen (Klinik für Nuklearmedizin), Sprache: Deutsch, Abstract: Die Radiojodtherapie (RJT) ist ein etabliertes Verfahren zur Behandlung des differenzierten Schilddrüsenkarzinoms (DTC). Sie beruht auf der biologischen Fähigkeit der differenzierten Schilddrüsenkarzinomzellen Jod zu speichern. Das Jod wird dabei aktiv über einen membranständigen Natrium-Jodid-Symporter in die Zellen transportiert. Diese selektive Anreicherung ermöglicht die Therapie mit Jod-131 (I-131), einem Beta- und Gamma-Strahler. Die therapeutische Wirkung der RJT beruht hauptsächlich auf die Energieübertragung durch die Beta-Strahlung. Aber nicht nur die Schilddrüsenkarzinomzellen sind in der Lage I-131 aktiv anzureichern, sondern auch andere Gewebszellen, die den Natrium-Jodid-Symporter exprimieren. Dazu zählen die großen Kopfspeicheldrüsen. Speziell konnte nachgewiesen werden, dass die großen Kopfspeicheldrüsen das I-131 bis zum 50-fachen der Plasmakonzentration konzentrieren. Aufgrund dieser Verteilung im Organismus kann eine "hochdosierte" RJT neben der erwünschten Zerstörung des tumorösen Schilddrüsengewebes auch zu I-131 induzierten Speicheldrüsenschädigung führen. Als Folge können sich chronische Speicheldrüsenbeschwerden, Xerostomie und dentale Erkrankungen einstellen. Die Energiedosen der großen Kopfspeicheldrüsen wurden mittels Gammakamera-Szintigraphie (GKS) und Ultraschall (US) während der RJT differenzierter Schilddrüsenkarzinome (DTC) mit I-131 kürzlich ermittelt und waren verglichen mit den bekannten Dosiswirkungsbeziehungen um den Faktor zehn zu niedrig. Die Quantifizierung der I-131 GKS/US-Dosimetrie war allerdings erschwert. Die Notwendigkeit einer genaueren Dosimetrie zeichnete sich ab. Die zurzeit genaueste in vivo Dosimetrie von I-131 speichernden Organen ist die Kombination aus Positronenemissionstomographie (PET) mit Jod-124 (I-124) als Tracer für das Therapienukl


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Product Details
  • ISBN-13: 9783640588633
  • Publisher: Grin Publishing
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Spine Width: 7 mm
  • Weight: 149 gr
  • ISBN-10: 3640588630
  • Publisher Date: 11 Apr 2010
  • Height: 210 mm
  • No of Pages: 108
  • Series Title: German
  • Sub Title: Untersuchung von wichtigen Einflussfaktoren auf die I-124 Quantifizierung
  • Width: 148 mm


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Prätherapeutische I-124 PET(/CT)-Speicheldrüsendosimetrie bei der Radiojodtherapie differenzierter Schilddrüsenkarzinome: Untersuchung von wichtigen Einflussfaktoren auf die I-124 Quantifizierung
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Prätherapeutische I-124 PET(/CT)-Speicheldrüsendosimetrie bei der Radiojodtherapie differenzierter Schilddrüsenkarzinome: Untersuchung von wichtigen Einflussfaktoren auf die I-124 Quantifizierung
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Prätherapeutische I-124 PET(/CT)-Speicheldrüsendosimetrie bei der Radiojodtherapie differenzierter Schilddrüsenkarzinome: Untersuchung von wichtigen Einflussfaktoren auf die I-124 Quantifizierung

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