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Protocolo Méduri e pneumonia por COVID-19: factores de insucesso terapêutico

Protocolo Méduri e pneumonia por COVID-19: factores de insucesso terapêutico

          
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About the Book

O SARS-CoV-2 causa SDRA, uma tempestade de citocinas e inflamação excessiva... A terapia com corticosteróides em altas doses pode ser indicada em pacientes que desenvolvem fibrose pulmonar. O objetivo do estudo foi identificar os factores que levam ao insucesso da terapêutica com corticosteróides em doses elevadas de acordo com o protocolo Meduri. Este estudo de coorte prospetivo foi realizado na unidade de cuidados intensivos do Hospital Taher Sfar em Mahdia. Todos os doentes hospitalizados com pneumonia por SARS-CoV-2 receberam metilprednisolona 2 mg/kg/d em doses progressivas ao longo de um mês. Num total de 178 doentes, o sucesso do tratamento foi de 33,7%, com uma taxa de mortalidade de 61%. Na análise multivariada, a pontuação SAPS II (OR=0,938, IC95% [0,895-0,982], p=0,007) e o uso de VNI (OR=0,416, IC95% [0,187-0,925], p=0,031) foram independentemente associados ao insucesso. O limiar SAPS II foi de 23,5 com uma sensibilidade de 75%, uma especificidade de 61%, um valor preditivo positivo de 54,55%, um valor preditivo negativo de 79,46% e uma área sob a curva de 0,724. Em conclusão, o score SAPS II e a utilização de VNI são factores de insucesso.


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Product Details
  • ISBN-13: 9786208190675
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Weight: 104 gr
  • ISBN-10: 6208190673
  • Publisher Date: 16 Oct 2024
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Sub Title: factores de insucesso terapêutico
  • Width: 152 mm


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