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Protocole Méduri et pneumonie COVID19: Facteurs d'échec thérapeutique

Protocole Méduri et pneumonie COVID19: Facteurs d'échec thérapeutique

          
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About the Book

Le SARS-CoV-2 provoque un SDRA, un orage de cytokines et une inflammation excessive.. La corticothérapie à forte dose pourrait être indiquée chez les patients qui développent une fibrose pulmonaire. L'objectif de l'étude était d'identifier les facteurs d'échec de la corticothérapie à forte dose selon le protocole de Meduri. Cette étude de cohorte prospective a été menée en réanimation à l'hôpital Taher Sfar de Mahdia. Tous les patients hospitalisés pour une pneumonie à SARS-CoV-2 ont reçu de la méthylprednisolone à 2 mg/kg/j en dose dégressive sur un mois. Sur 178 patients, le succès du traitement était de 33,7%, avec une mortalité de 61%. En analyse multivariée, le score de SAPS II (OR=0,938, IC95% [0,895-0,982], p=0,007) et l'utilisation de la VNI (OR=0,416, IC95% [0,187-0,925], p=0,031) étaient indépendamment associés à l'échec. Le seuil du SAPS II était de 23,5 avec une sensibilité de 75%, une spécificité de 61%, une valeur prédictive positive de 54,55%, une valeur prédictive négative de 79,46% et une zone sous la courbe de 0,724. En conclusion, le score de SAPS II et le recours à la VNI comme facteurs d'échec.


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Product Details
  • ISBN-13: 9786206720430
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Editions Universitaires Europeennes
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Weight: 104 gr
  • ISBN-10: 6206720438
  • Publisher Date: 09 Sep 2024
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Sub Title: Facteurs d'échec thérapeutique
  • Width: 152 mm


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