Tools and guidance from a team of experts to meet the challenges of the post-genomics era "Proteomics for Biological Discovery" presents the state of the art in the field of proteomics and offers readers new tools and techniques to advance their own research. Moreover, the publication provides readers with an understanding of new and emerging directions for proteomics research and applications.
The publication begins with an introduction that examines the rise of proteomics and discusses potential benefits, such as new diagnostics and therapeutics, that further proteome-level research promises. Next, the publication is divided into three sections: Foundations of Proteomics Functional Proteomics Novel Approaches in Proteomics
All the tools of proteomics, from conventional to novel techniques, are examined, including: Proteomic analysis using 2D-PAGE Gel-free proteomics to measure protein abundances Characterization of intact noncovalent protein complexes Three-dimensional protein structure determination Protein localization by imaging techniques Protein arrays
The publication also covers key foundations of proteomics: separations, bioinformatics, and automation. Each chapter, written by an expert, addresses technological limitations, emerging approaches, and key questions requiring further investigation. In addition, each chapter explores future applications for industry and basic science.
This reference brings readers in touch with a team of experts who are leading the proteomics revolution. It is, therefore, recommended for students and researchers across the gamut of fields in biomedical research, including biochemistry, protein chemistry, molecular genetics, celland developmental biology, and bioinformatics.
Written by recognized experts in the study of proteins, "Proteomics for Biological Discovery" begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics.Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applicationsChapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applicationsDiscusses higher level integrative aspects, including technical challenges and applications for drug discoveryAccessible to the novice while providing experienced investigators essential information
"Proteomics for Biological Discovery" is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.
