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Polimorfismo do gene IL-8 na pancreatite aguda biliar e não biliar

Polimorfismo do gene IL-8 na pancreatite aguda biliar e não biliar

          
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About the Book

As quimiocinas desempenham um papel importante no aparecimento e desenvolvimento de doenças inflamatórias. Além disso, devido à síndrome da resposta inflamatória sistémica que se desenvolve após o início das doenças, as complicações de outros órgãos resultam no desenvolvimento de disfunção de múltiplos órgãos. Sendo um ativador significativo para os neutrófilos, a quimiocina IL-8 desempenha um papel importante na cascata da inflamação. Tal como muitas outras doenças inflamatórias (psoríase, artrite reumatoide, doença pulmonar), os níveis séricos de IL-8 estão sobre-expressos na pancreatite aguda. Ao mesmo tempo, os efeitos extensivos do aumento da atividade da IL-8 na patogénese tumoral fazem dela um alvo terapêutico único na terapia do cancro. Por exemplo, a IL-8 promove o crescimento tumoral, a angiogénese e a metástase em modelos murinos de vários tipos de cancro. Além disso, o bloqueio da atividade da IL-8 com um anticorpo monoclonal demonstrou diminuir o crescimento tumoral em dois modelos murinos de cancro. O bloqueio da expressão de IL-8 em algumas linhas celulares de melanoma humano por RNA antisense mostrou que a IL-8 funciona como um modulador de crescimento autócrino para essas células. Assim, a İL-8 pode ser importante para a inflamação e o cancro.


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Product Details
  • ISBN-13: 9786208023188
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 6208023181
  • Publisher Date: 29 Aug 2024
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 104 gr


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