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Pharmakokinetische Studie und Rückstandsanalyse von Ciprofloxacin

Pharmakokinetische Studie und Rückstandsanalyse von Ciprofloxacin

          
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About the Book

In der vorliegenden Studie wurden die pharmakokinetischen Parameter von Ciprofloxacin nach oraler und i.v.-Verabreichung einer Einzeldosis bewertet und der Restspiegel sowie die Wartezeit abgeschätzt. Außerdem wurde die Sicherheit von Leber und Nieren nach mehrfacher oraler Verabreichung von Ciprofloxacin bei Hühnern mit doppeltem Verwendungszweck untersucht. Die Studie wurde an dreißig Tage alten Indian Rock-3-Vögeln (n=210) durchgeführt, einem vom Veterinary College, Bengaluru, entwickelten Zweinutzungshuhnstamm des White Plymouth Rock. Für die analytische Studie wurde die Flüssigchromatographie-Tandem-Massenspektrometrie verwendet, die eine hohe Spezifität und Empfindlichkeit aufweist. Für die pharmakokinetische Studie wurden die Vögel in zwei Versuchsgruppen (n=15) aufgeteilt. Den Vögeln der Gruppe I und der Gruppe II wurde eine Einzeldosis Ciprofloxacin in Höhe von 8 mg/kg PO bzw. 5 mg/kg IV für die pharmakokinetische Studie verabreicht. Die Parameter wurden durch eine nicht-kompartimentelle Analyse mit der PK-Solver-Software bestimmt. Für die Rückstandsanalyse und die Absetzzeit von Ciprofloxacin wurden die Versuchstiere in zwei Gruppen aufgeteilt. Gruppe I (n=10) diente als Kontrolle zur Standardisierung der Ausrüstung. Gruppe II (n=80) wurde oral mit Ciprofloxacin verabreicht.


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Product Details
  • ISBN-13: 9786205604021
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Verlag Unser Wissen
  • Height: 229 mm
  • No of Pages: 164
  • Spine Width: 10 mm
  • Width: 152 mm
  • ISBN-10: 6205604027
  • Publisher Date: 20 Jan 2023
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 249 gr


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