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Pharmacokinetics: An Introduction

Pharmacokinetics: An Introduction

          
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About the Book

I. Volume of Distribution.- II. Compartments.- 1. Protein Binding.- 2. Gastrointestinal Reabsorption.- III. Elimination.- 1. Equation for Elimination.- a) Theoretical Initial Concentration.- b) Half-Time of Elimination.- c) Rate Constant of Elimination.- d) Total Clearance.- e) Saturation Kinetics.- f) Determination of Pharmacokinetic Data from Urine.- IV. Steady State.- 1. Conditions for a Steady State.- a) The Exchangeable Pool.- b) Experimental Analysis of a Natural Steady State.- c) Endogenous Transfer.- 2. Artificial Steady State - Continous Infusion.- V. Multicompartment Systems.- 1. The Model.- a) Invasion.- b) Concentration-Time Curve for Simultaneous Invasion and Elimination.- c) The Bateman Function.- 2. Dost's Principle of Corresponding Areas.- a) Test of Completeness of Invasion.- b) Rule of Corresponding Areas as a Supplement to the Basic Pharmacokinetic Experiment.- 3. Dost's Rule of Corresponding Fractional Areas.- a) Fractional Quantities and Fractional Areas.- b) Conversion of Areas to Quantities of Substance.- 4. General Consideration of Multicompartment Models.- a) Multi-Exponential Function.- b) Subdivision into Individual e-Functions.- c) Practical Importance of the C; y-Expression.- VI. Pharmacokinetics and Treatment.- 1. Repeated Administration of a Drug.- a) Duration of Accumulation.- b) Degree of Accumulation.- VII. Pharmacokinetics of Gastrointestinal Absorption.- 1. Gastrointestinal Absorption and the Bateman Function.- 2. Reconstruction of the Invasion Curves.- 3. Use of the Invasion Curves.- 4. Calculation of Dose-Proportional Absorption.- 5. Variants of the Invasion Process in Gastrointestinal Absorption.- a) Variants in the Site of Absorption.- b) Delay in Invasion Due to Lymphatic Transport of Lipid-Soluble Substances.- c) Physical and Chemical Reactions After Absorption.- d) Excretion and Reabsorption of Substances in the Intestine.- e) Limitation of the Absorptive Capacity.- f) Different Absorptive Capacity of Two Segments of Intestine.- 6. Conclusions.- 7. Appendix: Some Formulae and Their Derivation.- VIII. Interaction.- 1 Elimination.- a) Pathological Changes in the Organ of Excretion.- b) Age-Dependent Changes in Elimination.- c) Pharmacogenetic Factors.- d) Dependence of Rate of Elimination on Acid-Base Balance.- e) Circadian Rhythm of Excretion Rate.- f) Water Diuresis and Rate of Elimination.- g) Solvent Deficiency.- h) Enzyme Induction.- i) Inhibition of Elimination by Toxicity.- 2. Volume of Distribution.- a) Hydration and Dehydration.- b) Hydropic States.- 3. Conclusions.- IX. Use of Analogue Computers in Pharmacokinetics.- 1. Principle of the Analogue Computer.- 2. Programming the Analogue Computer.- 3. Use.- X. Practical Application of Pharmacokinetic Procedures.- 1. Methods of Measurement.- a) Microbiological Methods.- b) Chemical Analysis.- c) Radioactively Labelled Substances.- 2. Assessment of the Results of Animal Experiments.- 3. Derivation of Pharmacokinetic Parameters and Constants.- a) Calculation from a Graph.- b) Programmend Procedures.- 4. Mathematical Basis of Programming.- a) Distribution of a Substance Between Several Compartments.- b) Blood Concentration-Time Curves for Pure Invasion.- c) Blood Concentration-Time Curves for Pure Elimination.- d) Blood Concentration-Time Curves for Simultaneous Invasion and Elimination (Batemann Function).- e) Accumulation, Limiting Curve.- f) Dosage Scheme.- 5. Examples of Calculation.- Further Reading.


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Product Details
  • ISBN-13: 9783540091837
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Height: 203 mm
  • No of Pages: 144
  • Series Title: English
  • Sub Title: An Introduction
  • Width: 133 mm
  • ISBN-10: 3540091831
  • Publisher Date: 01 Apr 1979
  • Binding: Paperback
  • Language: English
  • Returnable: Y
  • Spine Width: 9 mm
  • Weight: 190 gr


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