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Natural Antioxidants: An Approach Towards Tuberculosis Management

Natural Antioxidants: An Approach Towards Tuberculosis Management

          
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About the Book

Tuberculosis (TB) has been reported to have fifth highest fatality rate in the world, a disease claiming between 2 and 3 million lives a year. One of the important reasons why this killer parasite is spiraling out of control at an alarming rate is attributed to the prevalence of multidrug-resistant (MDR) strains and emergence of AIDS-related TB. Focus has now been shifted towards development of compounds from natural sources that have antimycobacterial activity. The incorporation of such compounds, like polyphenols namely Epigallocatechin-3-gallate (EGCG) from green tea, as the natural component of tuberculosis treatments has been studied here. Reactive oxygen species and tumor necrosis factor (TNF-α) are the hallmarks of tuberculosis. The augmented expression of TNF-α at both the gene and protein levels in MTB-infected monocytes is suppressed by EGCG in dose-dependent manner. Also, EGCG ameliorated the IFN-γ levels, the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF- α in MTB-infected monocytes. Hence, EGCG may prove to be a valuable natural antioxidant in tuberculosis management.


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Product Details
  • ISBN-13: 9783838394329
  • Publisher: Lap Lambert Academic Publishing
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 11 mm
  • Weight: 294 gr
  • ISBN-10: 3838394321
  • Publisher Date: 12 Aug 2010
  • Height: 229 mm
  • No of Pages: 196
  • Series Title: English
  • Sub Title: An Approach Towards Tuberculosis Management
  • Width: 152 mm


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Natural Antioxidants: An Approach Towards Tuberculosis Management
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