Home > Science & Mathematics > Biology, life sciences > Nachweis Von Ionotropen Und Metabotropen Purin-Rezeptoren in Der Retina Von Saugetieren
Nachweis Von Ionotropen Und Metabotropen Purin-Rezeptoren in Der Retina Von Saugetieren

Nachweis Von Ionotropen Und Metabotropen Purin-Rezeptoren in Der Retina Von Saugetieren

          
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About the Book

Die Retina von Saugetieren stellt einen vorgelagerten Teil des Gehirns dar. Sie besteht aus einem komplexen neuronalen Netzwerk mit 5 verschiedenen Neuronentypen, die in Schichten geordnet ubereinander liegen und miteinander verschaltet sind. Photorezeptoren in der ausseren Retina nehmen Lichtreize auf und wandeln diese in elektrische Signale um, die uber verschiedene andere neuronale Zellen transportiert, moduliert und schliesslich in die visuellen Zentren des Gehirns ubertragen werden. An der Verarbeitung der visuellen Informationen sind zahlreiche Neurotransmitter bzw. Neuromodulatoren beteiligt. Bei P2-Rezeptoren handelt es sich um erst seit den siebziger Jahren bekannte ionotrope und metabotrope Purin-Rezeptoren, die sowohl schnelle als auch langsamere Signalverarbeitung leisten konnen, ATP und UTP als spezifische Liganden aufweisen und im zentralen Nervensystem weit verbreitet sind. In der vorliegenden Arbeit wurde erstmals das Vorkommen und die Verteilung von zahlreichen P2X- und P2Y-Rezeptoren in der Retina von Ratten und Mausen untersucht. Dies geschah qualitativ mittels Einzelzell-RT-PCR in Ganglienzellen, Bipolarzellen und Mullerzellen von adulten Ratten bzw. mittels in-situ-Hybridisierung in histologischen Schnitten der Retina von adulten Ratten und Mausen und in einer Ratten-Entwicklungsreihe auf mRNA-Ebene; eine quantitative Beurteilung wurde durch P2-Proteindetektion mittels Western Blot in Gesamtretina-Proben von Ratten unterschiedlicher Entwicklugsstadien moglich. Diese drei Nachweismethoden ergaben, dass alle untersuchten P2-Subtypen (P2X2/3/4/5/7 und P2Y1/2/4/6) in allen ausgewahlten Altersstadien und sowohl auf mRNA-Ebene als auch auf Proteinebene vorkommen, wenn auch in unterschiedlicher Intensitat. Die hier beschriebenen Ergebnisse legen im Vergleich mit der aktuellen Literatur zu diesem und ahnlichen Themen nahe, dass Purine als Neurotransmitter bzw. Neuromodulatoren in der Retina von Saugern uber eine Aktivierung der zugehorigen Rezeptoren eine wichtige Rolle bei der Verarbeitung visueller Informationen spielen und ebenfalls an ophthalmologischen Erkrankungen beteiligt sind. Ein Einsatz von P2-Agonisten bzw. Antagonisten bei Patienten mit retinalen Erkrankungen ware somit nach weiterer wissenschaftlicher Erforschung der Funktionen von Purin-Rezeptoren denkbar.


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Product Details
  • ISBN-13: 9783832502782
  • Publisher: Logos Verlag Berlin
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 700 gr
  • ISBN-10: 3832502785
  • Publisher Date: 20 Jun 2003
  • Height: 210 mm
  • No of Pages: 181
  • Spine Width: 0 mm
  • Width: 145 mm


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