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Morphin Und Morphinähnlich Wirkende Verbindungen

Morphin Und Morphinähnlich Wirkende Verbindungen

          
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About the Book

Um den Umfang der vorliegenden Monographie in erträglichen Grenzen zu halten und eine größere Übersichtlichkeit zu wahren, wurden von der Literatur bis zum Jahre 1940 nur diejenigen Arbeiten besprochen, die wesentliches zur Pharmakologie des Morphin beitrugen und auch heute noch Geltung besitzen. Diese Beschränkung war um so eher möglich, als in der ausgezeichneten Mono- graphie von KRUEGER, EDDY und SUMWALT aus dem Jahr 1941 "The pharmacology of the opium alcaloids" die Weltliteratur bis zu diesem Zeitpunkt fast lückenlos gesammelt und kritisch besprochen worden ist. Dagegen wurde die Literatur nach 1940 bis Anfang 1957 nach Möglichkeit vollständig bearbeitet, wobei von klinischen Arbeiten allerdings nur diejenigen Berücksichtigung fanden, die für die Pharmakologie von Bedeutung sind. Das Jahr 1940 ist durch die Entdeckung der vollsynthetischen, morphinähnlich wirkenden Verbindungen ein Markstein in der Pharmakologie dieser wichtigen Therapeutica. Da infolge der fast unbegrenzten Variationsmöglichkeit der che- mischen Grundtypen jetzt Hunderte von Verbindungen mit morphinähnlicher Wirkung verfügbar wurden, konnte versucht werden, gemeinsames im chemischen Aufbau und in der Pharmakodynamie herauszuarbeiten. Dabei zeigte sich, daß die schmerzstillende Wirkung nicht die einzige, vielleicht nicht einmal die wich- tigste therapeutisch verwertbare Eigenschaft dieser Verbindungen ist. Deshalb wurde mit Absicht im Titel das Wort "Analgetica" vermieden und der allgemeinere Ausdruck "morphinähnlich wirkende Verbindungen" gewählt.


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Product Details
  • ISBN-13: 9783642533334
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Binding: Paperback
  • Height: 254 mm
  • No of Pages: 367
  • Series Title: Handbook of Experimental Pharmacology
  • Weight: 652 gr
  • ISBN-10: 3642533337
  • Publisher Date: 01 Jan 1957
  • Edition: 1957 ed.
  • Language: German
  • Returnable: N
  • Spine Width: 20 mm
  • Width: 178 mm


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