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Medullary Thyroid Carcinoma: Biology, Management, and Treatment of Sporadic and Hereditary Mtc

Medullary Thyroid Carcinoma: Biology, Management, and Treatment of Sporadic and Hereditary Mtc

          
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About the Book

Provisional text
This book offers a comprehensive overview of medullary thyroid carcinoma. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.



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Product Details
  • ISBN-13: 9783031803956
  • Publisher: Springer Nature Switzerland
  • Publisher Imprint: Springer
  • Height: 235 mm
  • No of Pages: 325
  • Sub Title: Biology, Management, and Treatment of Sporadic and Hereditary Mtc
  • ISBN-10: 3031803957
  • Publisher Date: 13 May 2025
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Width: 155 mm


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Medullary Thyroid Carcinoma: Biology, Management, and Treatment of Sporadic and Hereditary Mtc
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