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Mecanismos envolvidos na resistência à terapia com interferão alfa no HCV

Mecanismos envolvidos na resistência à terapia com interferão alfa no HCV

          
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About the Book

A infecção crónica pelo vírus da hepatite C é uma enorme carga de cuidados de saúde a nível mundial, que se estima custar, só nos EUA, mais de 5 biliões de dólares por ano. Até recentemente, o único tratamento eficaz actual era a terapia combinada com peg-interferão alfa e ribavirina (peg-IFNα+RBV), que é cara e tem efeitos secundários significativos, e só é eficaz em até 50% das pessoas infectadas com o genótipo 1 do HCV. A distribuição do genótipo em ambos os loci do SNP foi diferente de outros estudos baseados em populações norte-americanas e europeias. A inclusão de indivíduos co-infectados mostra que os polimorfismos IL28B nos dois loci não estão uniformemente distribuídos entre doentes com mono-infecção e co-infecções do HCV. A abordagem proteómica para identificar novas proteínas que podem ser úteis como biomarcadores para a resposta ao tratamento. Após a optimização do procedimento electroforético. Embora preliminares, os dados identificaram a haptoglobulina como uma proteína cujo padrão de expressão se correlacionou inversamente com o controlo da replicação após a terapia. O trabalho também tentou identificar marcadores genéticos virais e hospedeiros que contribuem para o sucesso e fracasso do tratamento do HCV.


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Product Details
  • ISBN-13: 9786205144534
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 228
  • Spine Width: 13 mm
  • Width: 152 mm
  • ISBN-10: 6205144530
  • Publisher Date: 21 Jul 2023
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 341 gr


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