Home > Medicine > Other branches of medicine > Anaesthetics > Lormetazepam: Experimentelle Und Klinische Erfahrungen Mit Einem Neuen Benzodiazepin Zur Oralen Und Intravenösen Anwendung
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Lormetazepam: Experimentelle Und Klinische Erfahrungen Mit Einem Neuen Benzodiazepin Zur Oralen Und Intravenösen Anwendung

Lormetazepam: Experimentelle Und Klinische Erfahrungen Mit Einem Neuen Benzodiazepin Zur Oralen Und Intravenösen Anwendung

          
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About the Book

Reproduktionsleistung der F 1 -Genera The results of animal toxicity studies tion wurden durch die Behandlung der demonstrate that lormetazepam is weIl Muttertiere bis zum Ende der Lakta tolerated at substantially elevated do tionsperiode nicht beeinflusst. sage levels administered daily over ex Eingehende reproduktionstoxikologi tended periods of time. In particular, sche Untersuchungen haben ebenfalls no evidence of cytotoxic, embryotoxic, keine nachteiligen Befunde ergeben. Bei teratogenic, mutagenic and carcinoge der Ratte wurden Dosierungen bis 1 g/kg nic effects was noted. gepruft. Beim Kaninchen fand sich un Pharmakokinetik und Biotransforma ter 50 mg/kg eine Verminderung der Zahl der Implantate. Aus der gleichzei tion tigen Beeintrachtigung der Futterauf Zur Ermittlung der tierexperimentellen nahme und der Korpermasseentwick Pharmakokinetik und Biotransforma lung der Muttertiere ist abzuleiten, dass tion wurde Lormetazepam in Form der sich in diesem Dosisbereich die Grenze in Position 5 14 C-markierten Substanz der Vertraglichkeit von Lormetazepam Ratten, Hunden und Affen per os und beim Kaninchen abzeichnete. Eine Em intravenos verabreicht (1,9). bryotoxizitatsstudie an Affen lasst auch Bei allen Spezies wurde Lormetazepam bei dieser Spezies bis zur hochsten ge enteral vollstandig resorbiert. Die Elimi pruften Dosis von 50 mg/kg per os kei nation der Gesamtradioaktivitat war ne embryo toxischen Effekte von Lor nach 4 Tagen abgeschlossen. Wahrend metazepam erkennen. Hinweise auf die Ratte den weitaus grossten Teil der teratogene Wirkungen wurden bei kei intravenos verabreichten Radioaktivi ner der untersuchten Tierarten festge tat mit den Faeces ausschied, elimi stellt."


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Product Details
  • ISBN-13: 9783540103875
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Height: 244 mm
  • No of Pages: 138
  • Series Title: Anaesthesiologie Und Intensivmedizin Anaesthesiology and Int
  • Sub Title: Experimentelle Und Klinische Erfahrungen Mit Einem Neuen Benzodiazepin Zur Oralen Und Intravenösen Anwendung
  • Width: 156 mm
  • ISBN-10: 3540103872
  • Publisher Date: 01 Sep 1980
  • Binding: Paperback
  • Language: German
  • Returnable: Y
  • Spine Width: 0 mm
  • Weight: 320 gr


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Lormetazepam: Experimentelle Und Klinische Erfahrungen Mit Einem Neuen Benzodiazepin Zur Oralen Und Intravenösen Anwendung
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