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Lesões de Células Gigantes

Lesões de Células Gigantes

          
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About the Book

Uma célula gigante é uma massa formada pela união de várias células distintas (geralmente macrófagos) que passam por um conjunto definido de interações intercelulares que resultam em última instância em uma célula multinucleada com um único compartimento citoplasmático. As células multinucleadas são normalmente encontradas em lesões orais e maxilofaciais. Células gigantes multinucleadas foram relatadas pela primeira vez em granulomas de tuberculose por Rokitansky e Langhans há mais de um século. Essas células gigantes são hoje reconhecidas como uma característica comum dos granulomas induzidos por estímulos imunológicos e não imunológicos ao nascimento. Assim, elas são encontradas em granulomas associados com a resposta imunológica à lepra da tuberculose e várias infecções fúngicas e parasitárias, assim como granulomas associados com a resposta não imunológica a agentes tóxicos como o berílio e o amianto e dois agentes não tóxicos como partículas de carbono, contas de plástico e partículas de ferro. Estudos recentes envolvendo muitos osteoclastos e células gigantes de corpo estranho revelaram uma série de fatores comuns, como vitronectina, uma proteína de adesão, proteína transmembrana específica de células dendríticas (DC- STAMP), um fator de fusão e um receptor de fusão de macrófagos que contribuem para a célula gigante.


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Product Details
  • ISBN-13: 9786204097770
  • Publisher: Edicoes Nosso Conhecimento
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 217 gr
  • ISBN-10: 6204097776
  • Publisher Date: 21 Sep 2021
  • Height: 229 mm
  • No of Pages: 140
  • Spine Width: 8 mm
  • Width: 152 mm


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