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La Pharmacodynamie Des Antibiotiques: Étude Sur Deux Anx

La Pharmacodynamie Des Antibiotiques: Étude Sur Deux Anx

          
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About the Book

L'exploitation des paramètres PK/PD permet d'optimiser l'antibiothérapie ainsi que les modalités d'administration. L'objectif principal de notre étude est d'évaluer jusqu'à quelle valeur de CMI, les concentrations sériques des béta-lactamines et des glycopeptides répondent aux pré-requis de la PK/PD. Les concentrations sériques des béta-lactamines et des glycopeptides dosés aux HUS en 2008 et 2009 ont été analysées. Ainsi pour la ceftazidime, la perfusion continue est préférable pour atteindre les objectifs de la PK/PD. Le céfépime devra ètre réservé aux infections à entérobactéries en administration discontinue et à la posologie usuelle. La perfusion continue de la pipéracilline-tazobactam devra ètre privilégiée. Mais le breakpoint de la pipéracilline-tazobactam vis à vis du Pseudomonas aeruginosa devra ètre révisé. Le breakpoint de l'imipénème vis à vis du Pseudomonas aeruginosa devra aussi ètre révisé. Concernant les glycopeptides l'objectif PK/PD est pleinement atteint pour des CMI faibles. Au breakpoint actuel des glycopeptides vis à vis du Staphylococcus aureus, l'emploi de la perfusion continue reste préférable. Les résultats de notre étude remettent en question les schém


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Product Details
  • ISBN-13: 9786131596469
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Height: 229 mm
  • No of Pages: 104
  • Series Title: Omn.Univ.Europ.
  • Sub Title: Étude Sur Deux Anx
  • Width: 152 mm
  • ISBN-10: 6131596468
  • Publisher Date: 28 Feb 2018
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 6 mm
  • Weight: 168 gr


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