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KLF2, a master regulator of peripheral B lymphocyte homeostasis

KLF2, a master regulator of peripheral B lymphocyte homeostasis

          
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About the Book

Lymphocytes play a prominent role in the combat of infectious diseases. For a sufficient but limited immune response it is essential that migration and activation of lymphocytes are strictly controlled. The transcription factor KLF2 modulates T lymphocyte egress from lymphoid organs by regulating S1P1. This is not the case for B cells. Instead, KLF2 regulates homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of β7 integrin. In mice with a B cell-specific deletion of KLF2, S1P1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring less B cells, fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were found. Upon thymus-dependent immunization, IgG titers were diminished and antigen-specific plasma cells were absent in the bone marrow. Furthermore this study provides first evidence that KLF2 is posttranslationally phosphorylated directly or indirectly by the PI3K signaling pathway.


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Product Details
  • ISBN-13: 9783838125725
  • Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Spine Width: 6 mm
  • Width: 152 mm
  • ISBN-10: 383812572X
  • Publisher Date: 18 Jul 2011
  • Height: 229 mm
  • No of Pages: 96
  • Series Title: German
  • Weight: 149 gr


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KLF2, a master regulator of peripheral B lymphocyte homeostasis
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KLF2, a master regulator of peripheral B lymphocyte homeostasis
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