Excerpt from The Johns Hopkins Hospital Bulletin, 1905, Vol. 16

Fat capable of visual demonstration is known, however, to occur very much more generally in the body tissues than was formerly held. This knowledge has come mainly since the introduction of the stains, Sudan III and Scharlach R and is the result of work of Sata, Stangl, Fischer, Herxheimer, Hansemann, Cordes, Erdheim, and others. They have shown that fat is present in almost all of the glands of the body and occurs there under normal conditions in some way associated with cell metabolism.

The almost constant presence of fat in the liver has been long recognized and its large amount distinguishes it from other organs, so that the liver is very generally regarded as a fat depot analogous to the adipose tissue. Perhaps here the fat may undergo some change preparatory to its utilization by the other cells and so stand in a different relation to liver cells. That fat is normally present in the epithelium of the salivary glands, pancreas, adrenal, testis, ovary, thyroid, thy mus, sweat and sebaceous glands, and breast is not so generally recognized. Of particular interest to the pathologist is the question of the occurrence of fat in the kidney and heart.

In the kidney iof many of the lower animals fat occurs under normal conditions, particularly in the straight tubules where it has a basal position in the cell. In the human kidney it seems that small amounts of fat may be normally present and that Slight amounts of fat cannot without other evidence be considered as pathological. However, any considerable ih crease of fat may be regarded as pathological.

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