Part I. General Rationale and Historical Perspective

Ch 1 - Rationale and Historical Perspective of Intraoperative Irradiation
Leonard L Gunderson, Felipe A Calvo, Christopher G Willett, and Louis B Harrison

Ch 2 - Radiobiology of Large Dose per Fraction Irradiation
Paul Okunieff, Srinath Sundararaman, Su Metcalfe, and Yuhchyau Chen

Part II. Methods and Techniques of Treatment

Ch 3 - Intraoperative Electron-Beam Irradiation (IOERT): Physics and Techniques
Peter Biggs, Christopher G. Willett, Harm Rutten, Mario Ciocca, Leonard L. Gunderson, and Felipe A. Calvo

Ch 4 - HDR-IORT: Physics and Techniques
Eli E Furhang, Jussi K Sillanpaa, Kenneth Hu, and Louis B Harrison

Ch 5 - Electronic Brachytherapy/Low KV IORT: Physics and Techniques
Uta Kraus-Tiefenbacher, Peter Biggs, Jayant Vaidya, and Dario Francescatti

Ch 6 - IORT with Electron Beam, High Dose Rate Brachytherapy or Low-KV/Electronic Brachytherapy:
Methodological Comparisons
Subir Nag, Christopher G. Willett, Leonard L. Gunderson, Louis B. Harrison, Felipe A. Calvo, and Peter Biggs

Part III. Normal Tissue Tolerance - IORT

Ch 7 - Normal Tissue Tolerance to IOERT, EBRT or Both: Animal Studies and Clinical
Zeljko Vujaskovic, Christopher G Willett, Joel E Tepper, Timothy J Kinsella, and Leonard L Gunderson

Ch 8 - Central Nervous System Tumors
David Ortiz de Urbina, Patrick Schueller, Normann Willich, Kintomo Takakura, Osami Kubo, and Felipe A. Calvo

Ch 9 - Head and Neck Cancer
Kenneth S. Hu, Sue Yom, Michael J. Kaplan, Louis B. Harrison, and Rafael Martinez-Monge

Ch 10 - Breast Cancer
Felix Sedlmayer, Jean-Bernard DuBois, Roland Reitsamer, Gerd Fastner, David Olilla, and Roberto Orecchia

Ch 11 - Lung Cancer
Javier Aristu, Felipe A. Calvo, Marta Moreno, Rafael Martínez, Jesús Herreros, Raquel Ciérvide, Jean Bernard Dubois, and Scott Fisher

Ch 12 - Gastric Cancer
Rafael Martinez-Monge, Miren Gaztañaga, Javier Álvarez-Cienfuegos, Robert C. Miller, and Felipe A. Calvo

Ch 13 - Pancreas Cancer
Robert C. Miller, Vincenzo Valentini, Adyr Moss, Giuseppe R D'Agostino, Matthew D. Callister, Theodore Hong, Christopher G. Willett, and Leonard L. Gunderson

Ch 14 - Bile Duct and Gallbladder Cancer
Takeshi Todoroki, Gernot M. Kaiser, Wolfgang Sauerwein, and Leonard L. Gunderson

Ch 15 - Primary Colorectal Cancer
Nils D. Arvold, Theodore S. Hong, Christopher G. Willett, Paul C. Shellito, Michael G. Haddock, Harm Rutten, Vincenzo Valentini, Brian Czito, and Leonard L. Gunderson

Ch 16 - Recurrent Colorectal Cancer
Michael G. Haddock, Heidi Nelson, Vincenzo Valentini, Leonard L. Gunderson, Christopher G. Willett, Harm Rutten, Felipe A Calvo, Lou Harrison, Warren Enker, and JL Garcia-Sabrido

Ch 17 - Retroperitoneal Sarcomas
Brian Czito, John Donohue, Christopher Willett, Doug Tyler, Ivy Petersen, Robert Krempien, Kenneth Hu, Felipe Calvo, Matthew Callister, Kaled Alektiar, Michael Eble,
and Ana Alvarez

Ch 18 - Extremity and Trunk Soft Tissue Sarcomas
Ivy A Petersen, Robert Krempien, Christopher Beauchamp, Michael Eble, Felipe Calvo, Ignacio Azinovic, Matthew A Callister, and Ana Alvarez

Ch 19 - Bone Sarcomas
Felipe A. Calvo, Luis Sierrasesumaga, Ana Patiño, Carmen González, Manuel González, Carlos Ferrer, Norman Willich, and José Cañadell

Ch 20 - Gynecologic Malignancies
Kaled M. Alektiar, Michael G. Haddock, Dennis Chi, Felipe A. Calvo, and Ivy A. Petersen

Ch 21 - Genitourinary Cancer
Marco Krengli, Felipe A. Calvo, Carlo Terrone, Michael Haddock, Jean-Michel Hannoun-Levi, Juliette Thariat, Jean-Pierre Gerard, and Roberto Orecchia

Ch 22 - Pediatric Malignancies
Nadia N. Issa Laack, Paula J. Schomberg, Suzanne Wolden, and Jesus Vazquez

Part V. Conclusions and Future Possibilities

Ch 23 - Conclusions and Future Possibilities - IORT
Leonard L G