Excerpt from On Infantilism From Chronic Intestinal Infection: Characterized by the Over-Growth and Persistence of Flora of the Nursling Period, a Study of the Clinical Course, Bacteriology, Chemistry and Therapeutics of Arrested Development in Infancy

Case II. Female, act. 9 years. Two Older children, always well. Normal infancy, nursed during early months. At end Of second year irritant medication followed by gastritis lasting several days and only slowly subsiding. Present illness dates from this. Slight signs of rickets somewhat antecedent to the gastritis. By third year nutrition was impaired and development became much retarded. Child markedly undersized, head slightly rachitic, digestive tract irritable, carbohydrates very badly tolerated, fat absorption much impaired, abdomen much distended. By fourth year walking still very imperfect and child much undersized. Weight at this time not recorded, but nutrition much impaired and remained so during fourth, fifth, and sixth years. Throughout this time there were moderate anaemia, fat diarrhoea, grayish, voluminous, gas-holding, indolic stools. Urine regularly gave intense indican reactions. Ethereal sulphates, phenols and aromatic oxyacids regularly much increased, micturi tion often extremely frequent. During this entire period emo tional instability, peevishness, great physical langour, walking quickly followed by fatigue. In sixth year, after more than a year Of careful regulation of diet, gradual improvement in nutri tion, and gain in physical strength with Slow disappearance of neuromuscular disorders. Simultaneously gradual diminution of putrefactive products in urine and pronounced improvement in feces, which became formed, colored, Of normal fat content and nearly free from indol and phenol. Gradual appearance of B. Lactis aerogenes and B. Coli in large numbers in the feces. At Six and one-half years weight rose to 45 lbs. During next year gained 2 lbs. During following year gained 10 lbs., to 58 lbs. During last six months gained 7 lbs. With rapid gain in stature. Onset of epileptiform seizures during this period with return of putrefactive products in urine.

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