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Imagable 4t1 Model for the Study of Late Stage Breast Cancer

Imagable 4t1 Model for the Study of Late Stage Breast Cancer

          
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About the Book

The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modified to facilitate analysis of tumor growth and metastasis and evaluation of gene function in vivo. New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported. The production of factors that stimulate angiogenesis and ECM modification and induce hematopoiesis, recruitment and activation of leukocytes suggest that 4T1 tumor cells play a more direct role than previously appreciated in orchestrating changes in the tumor environment conducive to tumor cell dissemination and metastasis. The new cell lines will greatly facilitate the study of late stage breast and preclinical assessment of cancer drugs and other therapeutics particularly those targeting immune system effects on tumor metastasis. Proceeds from the sale of this book go to the support of an elderly disabled person.


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Product Details
  • ISBN-13: 9781517098919
  • Publisher: Createspace Independent Publishing Platform
  • Publisher Imprint: Createspace Independent Publishing Platform
  • Height: 276 mm
  • No of Pages: 48
  • Series Title: English
  • Weight: 17706 gr
  • ISBN-10: 1517098912
  • Publisher Date: 31 Aug 2015
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Spine Width: 3 mm
  • Width: 213 mm


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