Summary The Voice of Clinical Reason The world's most trusted internal medicine resource-fully updated with timely new chapters on the most important issues facing medical professionals Harrison?s Principles of Internal Medicine is the world's most trusted clinical medicine text-and a superb resource for learning the art and science of clinical reasoning. Written and edited by the world?s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Generations of medical professionals have trusted Harrison?s for the latest in disease mechanisms, clinical trial results and recommended guidelines, radiographic images, therapeutic approaches and specific treatments, practical clinical decision trees and algorithms, and much more. Salient Features Salient Features1. Voice of authority: Harrison?s is a bottom-line resource for clinicians pondering the validity of recommendations in other medical resources. 2. Integrity: Customers around the world rely on Harrison's and know they can trust the integrity of the content. 3. World-renowned experts: Harrison's is written and edited by physicians and scientists who know their fields as well as anyone on earth. 4. Heavily illustrated: Over the past few editions, hundreds of quality diagrams and schematics and radiographs have been added, bolstering Harrison?s reputation as one of the best-illustrated medical texts available. 5. Updated Content: This edition features up-to-date coverage on the diagnosis and treatment of diseases, including pandemic, sepsis, dementia, multiple sclerosis, and lung cancer; new approved therapeutics; new practice-changing guidelines and evidence summaries; and more. 6. New Chapters: Approaches to Diagnostic Accuracy; Vaccine Hesitancy and Opposition; Precision Medicine; Regulation and Dysregulation of the Immune System, Interventional Nephrology, and many more. About the Author Joseph Loscalzo, MD, PhD, (Boston, MA) is Hersey Professor of the Theory and Practice of Medicine at Harvard Medical School, Chairman of the Department of Medicine, and Physician-in-Chief at Brigham and Women's Hospital. Anthony S. Fauci, MD, (Bethesda, MD) is Chief of the Laboratory of Immunoregulation and Director of the National Institutes of Allergy and Infectious Diseases for the National Institutes of Health. Dennis L. Kasper, MD, (Boston, MA) is William Emery Channing Professor of Medicine and Professor of Microbiology and Molecular Genetics at Harvard Medical School. Stephen L. Hauser, MD, (San Francisco, CA) is Robert A. Fishman Distinguished Professor of Neurology and Director of the UCSF Weill Institute for Neurosciences for the University of California, San Francisco. Dan L. Longo, MD, (Boston, MA) is Professor of Medicine at Harvard University School of Medicine and Deputy Editor of Oncology for the New England Journal of Medicine. J. Larry Jameson, MD, PhD, (Philadelphia, PA) is Robert G. Dunlop Professor of Medicine; Dean of Raymond and Ruth Perelman School of Medicine; and Executive Vice President of the University of Pennsylvania for the Health System.