Part I. The Haemostatic System
1. The Coagulation System in Humans
Anthony K. C. Chan and Nethnapha Paredes
2. Platelet Physiology
Matthew D. Linden
3. The Role of the Blood Vessel Wall
Nethnapha Paredes and Anthony K. C. Chan
Part II. General Principles of Haemostatic Testing
4. Specimen Requirements for the Haemostasis Laboratory
Linda Stang and Lesley G. Mitchell
5. Principles of Haemostasis Tests
Gemma Crighton
6. Reference Ranges of Coagulation Tests
Oliver Speer, Markus Schmugge, Claudia Metzger, and Manuela Albisetti
7. Lupus Anticoagulant Testing
Karen Moffat, Anne Raby, and Mark Crowther
Part III. Examples of Global Tests of Haemostasis
8. Activated Partial Thromboplastin Time (APTT)
Vera Ignjatovic
9. Prothrombin Time (PT) and International Normalised Ratio (INR)
Vera Ignjatovic
10. Thrombin Clotting Time (TCT)
Vera Ignjatovic
11. Thrombin Generation
Leslie R. Berry and Anthony K. C. Chan
12. Activated Clotting Time (ACT)
Stephen Horton and Simon Augustin
Part IV. Examples of Tests for Bleeding Disorders
13. Factor XII Assays
Stephen Opat, Jenny Butler, Erica Malan, Elizabeth Duncan, and Huyen A.M. Tran
14. Fibrinogen
Linda Stang and Lesley G. Mitchell
15. Platelet Counting
Sylvain Salignac, Véronique Latger-Cannard, Nicole Schlegel, and Thomas Lecompte
16. Platelet Morphology Analysis
Véronique Latger-Cannard, Odile Fenneteau, Sylvain Salignac, Thomas Lecompte, and Nicole Schlegel
17. Light Transmission Aggregometry
Juan Pablo Frontroth
18. Platelet Flow Cytometry
Matthew D. Linden
Part V. Examples of Specific Assays Related to Anticoagulant Activity
19. Anti-factor Xa assay (anti-Xa)
Fiona Newall
20. Reptilase Time (RT)
Hratsch Karapetian
21. Protamine Titration
Fiona Newall
22. Laboratory Methods for the Assay if Tissue Factor Pathway Inhibitor (TFPI) in Human Plasma
Robyn Summerhayes
23. Heparin Induced Thrombocytopenia (HIT)
Andreas Greinacher, Birgitt Fürll, and Sixten Selleng
Part VI. Examples of Tests for Inhibitors of Coagulation
24. Nijmegen-Bethesda Assay to Measure Factor VIII Inhibitors
Elizabeth Duncan, Margaret Collecutt, and Alison Street
25. Kaolin Clotting Time
Kottayam Radhakrishnan
26. The Dilute Russell Viper Venom Time (DRVVT)
Kottayam Radhakrishnan
27. Platelet Neutralisation Test
Kottayam Radhakrishnan
Part VII. Examples of Tests for Increased Risk of Thrombosis
28. Antithrombin
Mirta Hepner and Vasiliko Karlaftis
29. Protein C
Mirta Hepner and Vasiliki Karlaftis
30. Protein S
Mirta Hepner and Vasiliki Karlaftis
31. Testing for Hyperhomocysteinemia in Subjects with a History of Thromboembolic Events Using HPLC Technique
Jonas Denecke
32. Anticardiolipin Antibody and Anti-Beta 2 Glycoprotetin I Assays
Anne Raby, Karen Moffat, and Mark Crowther
33. Testing for Apolipoprotein (a) Phenotype Using Isoelectric Focusing and Immunoblotting Technique
