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Formulação e Caracterização do Gel de Diclofenac de Sódio

Formulação e Caracterização do Gel de Diclofenac de Sódio

          
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About the Book

No presente estudo, pode concluir-se que foram preparadas formulações tópicas em gel contendo o medicamento Diclofenac sódico com diferentes concentrações de agentes gelificantes (carbopol-940/934/ HPMC 3K), que apresentaram resultados aceitáveis em vários estudos de avaliação. O gel foi caracterizado com base em vários parâmetros de avaliação. Todo o gel preparado apresentou propriedades físicas aceitáveis em termos de cor, odor, consistência, uniformidade, homogeneidade, valor de pH, viscosidade e espalhabilidade. Foi efectuado um estudo in vitro de libertação do fármaco utilizando uma membrana de ovo, utilizando a célula de difusão de Franz (dolphin). Os resultados indicam que, em mais de 24 horas de estudo total, até 90,12% do fármaco diclofenac sódico é libertado através da membrana. De acordo com os resultados obtidos neste estudo, concluiu-se que o diclofenac sódico foi incorporado com êxito na formulação de carbopol para obter um gel. A formulação de gel F5 apresentou um bom valor de pH, condutividade, viscosidade, espalhabilidade e estabilidade antes e depois dos 12 dias do ciclo de congelação-descongelação. Por conseguinte, concluiu-se que a formulação F5 poderia ser uma alternativa muito promissora para o tratamento tópico ou transdérmico.


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Product Details
  • ISBN-13: 9786206882657
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 56
  • Spine Width: 3 mm
  • Width: 152 mm
  • ISBN-10: 6206882659
  • Publisher Date: 27 Nov 2023
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 95 gr


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