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Formulation Et Évaluation d'Un Film de Chlorpromazine À Dissolution Rapide

Formulation Et Évaluation d'Un Film de Chlorpromazine À Dissolution Rapide

          
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About the Book

Le vomissement est l'expulsion involontaire et forcée du contenu de l'estomac par la bouche et parfois par le nez. Les récepteurs situés au fond du ventricule du cerveau représentent une zone de déclenchement des chimiorécepteurs, appelée zone postrema, dont la stimulation peut entraîner des vomissements. Le chlorpromazine HCl est formulé sous forme de film sublingual. Les films formés par HPMC K-15 à une concentration de 120 mg ont montré le caractère souhaitable pour un film sublingual. Les films optimisés formés ont été soumis à des paramètres d'évaluation, à savoir la résistance à la traction, la désintégration, la dissolution in vitro, des études de perméation ex vivo et des études in vivo, et les résultats ont été conformes aux données statistiques disponibles. Les études de dissolution in vitro ont été analysées et le modèle Higuchi s'est avéré être le meilleur modèle pour les études de dissolution in vitro avec une valeur de régression de 0,9248. Les études de perméation ex vivo ont montré une perméation cinq fois plus importante du médicament à partir de films par rapport au médicament pur. En conclusion, un film sublingual de chlorpromazine HCl peut entraîner une meilleure observance du patient, un début d'action rapide et une biodisponibilité accrue.


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Product Details
  • ISBN-13: 9786200906519
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Sciencia Scripts
  • Height: 229 mm
  • No of Pages: 124
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 6200906513
  • Publisher Date: 07 Jul 2020
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Weight: 191 gr


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Formulation Et Évaluation d'Un Film de Chlorpromazine À Dissolution Rapide
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