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Estudo de modelo de inibição de calicreínas teciduais humanas 5 e 7

Estudo de modelo de inibição de calicreínas teciduais humanas 5 e 7

          
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About the Book

A descoberta de um novo fármaco é um processo laborioso que demanda tempo e dinheiro. Nos últimos anos, a indústria farmacêutica e a academia vem utilizando de ferramentas de bioinformática junto à ensaios biofísicos pra diminuir o tempo e custos com essas descobertas. Neste livro veremos um exemplo de como esse trabalho pode ser desenvolvido. As calicreínas teciduais humanas 5 e 7 são enzimas envolvidas no processo de descamação da pele. Quando os processos de regulação falham, doenças como a psoríase surgem. A descoberta de inibidores de modo aleatório seria laborioso. Assim, partindo da premissa que compostos isocumarínicos apresentam atividade inibitória, fizemos estudo de interação e inibição dessas enzimas por ensaios fluorométricos e análise do modo de interação por bioinformática. Os dados experimentais e teóricos corroboram no desenho de fármacos mais potentes.


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Product Details
  • ISBN-13: 9783639741407
  • Publisher: Novas Edicoes Academicas
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Spine Width: 5 mm
  • Width: 152 mm
  • ISBN-10: 3639741404
  • Publisher Date: 08 Jan 2015
  • Height: 229 mm
  • No of Pages: 76
  • Series Title: Portuguese
  • Weight: 123 gr


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