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Estrés oxidativo y retinopatía diabética: tratamiento con ácido lipoico

Estrés oxidativo y retinopatía diabética: tratamiento con ácido lipoico

          
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About the Book

La retinopatía diabética (RD) es la primera causa de ceguera en los países desarrollados.La RD es una enfermedad tanto vascular, ya que produce alteraciones en la microcirculación ocular, como una enfermedad neurodegenerativa, con atrofia de las células ganglionares y de la capa nuclear interna.Los mecanismos fisiopatológicos son múltiples, entre ellos el estrés oxidativo.El ácido lipoico (AL) es un antioxidante natural, presente en el ser humano a través de la dieta, y actúa como co-enzima en reacciones mitocondriales y como antioxidante universal.Los modelos de diabetes experimental en ratón han demostrado un aumento del estrés oxidativo de las células retinianas con alteración de los sistemas de defensa antioxidante.El tratamiento con suplementos de AL en un modelo de RD experimental tiene efectos sobre el desarrollo de la microangiopatía y las alteraciones neuronales que se producen en la retina como consecuencia de la DM. El AL disminuye los efectos del estrés oxidativo como consecuencia de la hiperglucemia crónica, mantiene la función retiniana en valores normales al menos en fases iniciales de la RD y además, reduce el número de células retinianas apoptóticas.


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Product Details
  • ISBN-13: 9783639557077
  • Publisher: Publicia
  • Binding: Paperback
  • Language: Spanish
  • Returnable: N
  • Spine Width: 15 mm
  • Weight: 385 gr
  • ISBN-10: 3639557077
  • Publisher Date: 26 May 2014
  • Height: 229 mm
  • No of Pages: 260
  • Series Title: Spanish
  • Sub Title: tratamiento con ácido lipoico
  • Width: 152 mm


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