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Esferas de emulsão flutuante de Gelucire para Metronidazol e Norfloxacina

Esferas de emulsão flutuante de Gelucire para Metronidazol e Norfloxacina

          
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About the Book

Gelucire, que compreende uma mistura de glicéridos puros (mono, di e triglicéridos de ácidos gordos saturados), misturas de glicéridos e ésteres de ácidos gordos de polietilenoglicóis (ésteres de ácidos gordos mono e di) em várias proporções ou ésteres de polietilenoglicol (PEG) puros sem a presença de glicéridos, como no caso do Gelucire 55/18. Estes são materiais lipídicos inertes feitos à medida, derivados de óleos e gorduras naturais hidrogenados de qualidade alimentar. Geralmente, são sintetizados por uma reação de alcoólise em que o óleo de coco, de palma ou de palmiste é hidrolisado e os ácidos gordos são removidos por destilação fraccionada. Estes ácidos gordos são então esterificados com PEG sob uma atmosfera de azoto. Para além da alcoólise, pode também ser fabricado por esterificação direta de ácidos gordos com glicerol e PEG. Os gelucires são excipientes com carácter anfifílico. O carácter anfifílico da base é atribuído à longa cadeia de hidrocarbonetos e às moléculas de álcool que tornam estas bases adequadas como transportadores lipídicos para fármacos hidrofílicos e lipofílicos. Estas bases foram desenvolvidas para fundir dentro de gamas especificadas e para ter características pré-determinadas de solubilidade em gordura ou de dispersão em água.


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Product Details
  • ISBN-13: 9786207864713
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 116
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 6207864719
  • Publisher Date: 29 Jul 2024
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 181 gr


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Esferas de emulsão flutuante de Gelucire para Metronidazol e Norfloxacina
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