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Effetti della Punica granatum e/o della Sitagliptina sulla nefropatia diabetica nei ratti maschi

Effetti della Punica granatum e/o della Sitagliptina sulla nefropatia diabetica nei ratti maschi

          
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About the Book

Il diabete mellito di tipo 2 (T2DM) rappresenta circa il 90% dei casi di diabete. La nefropatia diabetica è una delle complicazioni più gravi del diabete. La sitagliptina ha un ruolo importante nel potenziamento del recettore peptidico simile al Glucagone (GLP-1R) che è presente nei reni, quindi può avere un ruolo nel potenziamento della funzione renale nel T2DM. Inoltre, l'estratto di buccia di punica granatum (PGPE) è un'erba che ha un'attività antiiperglicemica e antiossidante. Questo studio è stato progettato per indagare il ruolo del PGPE e/o della sitagliptina sulle funzioni renali nel diabete indotto. I risultati del presente lavoro hanno dimostrato che la somministrazione di streptozotocin-nicotinamide induce stress ossidativo, infiammazione e iperglicemia indotta da streptozotocin-nicotinamide che svolgono un ruolo significativo nel diabete e le sue complicanze. Il miglioramento è dovuto alle azioni antidiabetiche, antinfiammatorie e antiossidanti della sitagliptina e della punica granatum peels. La combinazione di Punica granatum e sitagliptina rispetto alla monoterapia ha migliori effetti renoprotettivi nei ratti diabetici.


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Product Details
  • ISBN-13: 9786203057225
  • Publisher: KS Omniscriptum Publishing
  • Publisher Imprint: Edizioni Sapienza
  • Height: 229 mm
  • No of Pages: 224
  • Spine Width: 13 mm
  • Width: 152 mm
  • ISBN-10: 6203057223
  • Publisher Date: 21 Dec 2020
  • Binding: Paperback
  • Language: Italian
  • Returnable: N
  • Weight: 335 gr


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