Diabetes is a chronic disease and is a group of metabolic disorders characterized by
hyperglycemia. More than 230 million people worldwide are affected, and it is expected
to reach 350 million by 2025. Globally the affected people are unaware of the disease and
only half receive adequate treatment . Diabetes is associated with long-term
complications of peripheral nervous system and the central nervous system. Diabetic
neuropathy is a common complication of diabetes that results in damage to the nerves due
to high blood sugar levels for a long period of time. There are four types of diabetic
neuropathy- peripheral, autonomic, proximal, and focal.
In 2013, there were 65.1 million people between 20 and 79 years of age with diabetes in
India and this number was predicted to rise to 109 million by 2035. The management of
diabetes and its complications can be expensive, which poses serious obstacles to the
strengthening of the Indian health care system and the Government's plan to achieve
universal health coverage by 2022. Diabetic neuropathy (DN) is the most common
change and complication that affect more than 50% of patients with diabetes. It is one of
the leading causes of death in the world; thus, preventive measures are necessary for
patients with diabetes from developing neuropathy.
Allium cepa Lam. is a common and medicinally valuable plant. Leaves are reported to be
aphrodisiac, anti-spasmodic, antihelmintic, alterative, carminative, digestive, diuretic,
emollient, expectorant, mild laxative, stimulant and tonic along with presence of
flavonoids27, Vitamin A, thiamin and ascorbic acid28. Outer layers of scales of its bulbs in
different varieties were studied by researchers for their effects on chronic constriction
injury induced neuropathic pain and resulted into significant antioxidant effect and
improvement in neuropathic pain.
Ficus carica Lam. belongs to order Urticales and family Moraceae. It is cultivated
worldwide for its edible fruit. Fruits are a rich source of phenolic acids, vitamins,
minerals, and organic acids. Conventionally, it has medicinal benefits for ailments of
cardiovascular, respiratory, spasmodic, and inflammatory problems. Leaf extract has
shown significant hypoglycemic effect
