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Efecto del Film Sobre La Produccion de Citocinas En Linfocitos T Cd4+

Efecto del Film Sobre La Produccion de Citocinas En Linfocitos T Cd4+

          
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About the Book

El Factor Inhibidor de la Locomoción de Monocitos (FILM), pudiera contribuir a la exigua inflamación tardía observada en el absceso hepático amibiano, a través de efectos que ejerce directamente sobre los monocitos o indirectamente, modulando la producción o expresión de citocinas involucradas en el reclutamiento de células mononucleares al foco inflamatorio. En este trabajo evaluamos el efecto del FILM sobre la expresión de citocinas pro y anti-inflamatorias a nivel de gen y de proteína en linfocitos T CD4+ a las 24 h de incubación con RPMI, FILM, PMA, y PMA+FILM. El FILM incrementa la expresión del factor de activación CD69 en estas células lo que sugiere que el FILM se comporta como un agente inductor/activador. La expresión del gen y de proteínas de citocinas IL-1β, IFN-γ, IL-2, IL-4 e IL-10 y su co-localización con receptores de quimiocinas IL-1β/CCR5, IFN-γ/CCR5, IL-2/CCR5, IL-4CCR4 e IL-10/CCR4 son producidos por efecto del FILM. Mientras que la producción inducida por PMA de IL-1β, IFN-γ, fue inhibida por el FILM. La expresión de IL-10 fue incrementada por el FILM. El FILM inhibió a las citocinas pro-inflamatorias IL-1β, IFN-γ e incrementó la anti-inflamatoria IL-10.


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Product Details
  • ISBN-13: 9783848464081
  • Publisher: Eae Editorial Academia Espanola
  • Publisher Imprint: Eae Editorial Academia Espanola
  • Height: 229 mm
  • No of Pages: 76
  • Series Title: Spanish
  • Weight: 127 gr
  • ISBN-10: 384846408X
  • Publisher Date: 17 Apr 2012
  • Binding: Paperback
  • Language: Spanish
  • Returnable: N
  • Spine Width: 5 mm
  • Width: 152 mm


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Efecto del Film Sobre La Produccion de Citocinas En Linfocitos T Cd4+
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