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Converging Molecular Mechanisms in Cerebellar Ataxias

Converging Molecular Mechanisms in Cerebellar Ataxias

          
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About the Book

Cerebellar ataxias are a group of genetic disorders characterized by the degeneration of the cerebellum, a part of the brain that plays a critical role in motor coordination and motor learning. Recent advances in functional genomics have led to the identification of several genes associated with different subtypes of cerebellar ataxia. However, the molecular mechanisms underlying these disorders remain poorly understood. In this context, the study of converging molecular mechanisms in cerebellar ataxias has emerged as a promising approach for understanding the pathophysiology of these disorders. The cerebellum is a complex structure composed of different types of cells that interact with each other to perform specific functions. The identification of genes linked to ataxic subphenotypes has provided new insights into the molecular pathways that are involved in the development and progression of cerebellar ataxias. Several studies have shown that genetic mutations affecting protein folding, mitochondrial function, ion channels, calcium signaling, DNA damage, and RNA processing can lead to cerebellar degeneration and ataxia. Moreover, recent research has shown that molecular mechanisms involved in synaptic plasticity, neuroinflammation, oxidative stress, autophagy, ubiquitin-proteasome system, and protein homeostasis play a critical role in cerebellar function and dysfunction. Dysregulation of these cellular processes can lead to protein aggregation and cellular metabolism dysfunction, which in turn, can trigger neurodegeneration and ataxia. The use of functional genomics and molecular biology techniques has led to the identification of several biomarkers and therapeutic targets for cerebellar ataxias. These advances have paved the way for the development of new diagnostic tools and potential treatments for these devastating neurological disorders. Clinical trials are currently underway to evaluate the efficacy of different drugs and therapies aimed at targeting converging molecular mechanisms involved in cerebellar ataxias. In conclusion, the study of converging molecular mechanisms in cerebellar ataxias is a promising approach for understanding the pathophysiology of these disorders. It has the potential to provide new insights into the molecular pathways involved in cerebellar function and dysfunction, identify new biomarkers and therapeutic targets, and ultimately lead to the development of effective treatments for these devastating genetic disorders.


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Product Details
  • ISBN-13: 9798868933257
  • Publisher: Self Publisher
  • Publisher Imprint: Self Publisher
  • Height: 229 mm
  • No of Pages: 124
  • Spine Width: 7 mm
  • Width: 152 mm
  • ISBN-10: 886893325X
  • Publisher Date: 16 Oct 2023
  • Binding: Paperback
  • Language: English
  • Returnable: Y
  • Weight: 177 gr


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