Oxycodone or OxyContin drug is an opioid analgesic, or 'painkiller' drug that is most often prescribed to control moderate to severe pain that cannot be treated with other medications. It is a semi-synthetic opiate that was first created in 1916 from the baine, a chemical found in poppy plants and related to other narcotic drugs, such as morphine and heroin. Oxycodone was first developed as part of an effort to find non-addictive alternatives to these drugs, which were commonly used in medicine before and during World War I. Unfortunately, oxycodone also has significant potential for abuse and addiction. Like all opiates, it works by binding to opioid receptors in the brain and spinal cord, and these receptors are responsible for both: Although the US only accounts for approximately 5% of the world's population, the National Institute on Drug Abuse (NIDA) estimates that 81% of the world's supply of oxycodone is now consumed. The drug has been in clinical use since 1917. Parenteral oxycodone was used mainly for the treatment of acute postoperative pain whereas combinations, for example, oxycodone and acetaminophen, were used for moderate pain. Since the introduction of controlled-release oxycodone, it has been used to manage cancerrelated pain and chronic non-cancer-related pain problems. Controlled studies have been performed in postoperative pain, cancer pain, osteoarthritis-related pain, and neuropathic pain due to postherpetic neuralgia and diabetic neuropathy. The pharmacodynamics effects of oxycodone are typical of a μ-opioid agonist. Oxycodone closely resembles morphine but it has some distinct differences, particularly in its pharmacokinetic profile. Being an old drug, the basic pharmacology of oxycodone has been a neglected field of research. It is clinical research advises for Oxycodone to be withdrew for Individuals who develop dependence on oxycodone and suddenly stop taking it may experience withdrawal symptoms including: panic attacks, anxiety, gastrointestinal distress, muscle weakness, fever and flu-like symptoms. Withdrawal is extremely unpleasant and can cause users to persist in taking the drug despite negative effects on their life and finances. This addictive spiral can cause users to become depressed and, in extreme cases, even attempt suicide. This has caused a lot of controversies on USA.I recommend the rest of the world to learn from self-prescription of oxycodone particularly in African countries that regulated laws on self-medication are not practiced.