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Coeur Et Connexines. Morphogenèse Cardiaque, Propagation de l'Influx

Coeur Et Connexines. Morphogenèse Cardiaque, Propagation de l'Influx

          
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About the Book

Ce livre est le fruit d'un travail de thèse visant à apprécier le rôle des canaux jonctionnels dans la morphogenèse cardiaque et la propagation de l'activité électrique. Ces canaux sont des dodécamères de protéines transmembranaires appartenant à la famille des connexines (Cx). Le lecteur découvrira des informations détaillées sur les propriétés et les fonctions biologiques assurées par ces canaux dans l'organisme puis dans le coeur. L'activité électrique, générée dans le noeud sino-auriculaire se propage dans les oreillettes et les ventricules via ces canaux de Cx dont trois membres au moins sont exprimés dans les cardiomyocytes: les Cx40, -43 et -45. La compréhension de la morphogenèse cardiaque et de la propagation de l'activité électrique passe par une connaissance détaillée du patron d'expression de ces Cx. Le premier objectif de ce travail fut de déterminer, chez la souris, le patron d'expression de la Cx45 au cours de la morphogenèse cardiaque et au stade adulte. Le deuxième objectif fut de tenter de mieux comprendre le rôle des Cx dans la physiologie cardiaque par l'étude de souris Cx40KICx45 dans lesquelles nous avons substituté le gène de la Cx40 par celui de la Cx45.


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Product Details
  • ISBN-13: 9783838180175
  • Publisher: Univ Europeenne
  • Binding: Paperback
  • Language: French
  • Returnable: N
  • Spine Width: 20 mm
  • Width: 152 mm
  • ISBN-10: 3838180178
  • Publisher Date: 28 Feb 2018
  • Height: 229 mm
  • No of Pages: 356
  • Series Title: Omn.Univ.Europ.
  • Weight: 521 gr


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